Czirják L, Dankó K, Sipka S, Zeher M, Szegedi G
Ann Rheum Dis. 1987 Apr;46(4):302-6. doi: 10.1136/ard.46.4.302.
In vitro functions of polymorphonuclear (PMN) neutrophils were studied in 20 patients with progressive systemic sclerosis (PSS). An increase in the basal chemiluminescence (CL) activity of peripheral blood PMNs was found, suggesting that these cells had been preactivated in vivo. Patients with more extensive skin disease or signs of disease progression tended to have higher basal CL values. Active oxygen products during the respiratory burst may increase the extent of inflammatory and fibrotic processes and could be involved in the endothelial injury in PSS. The stimulatory capacity of CL response was normal in our study. No alterations were found in the opsonised yeast phagocytic activity of granulocytes when compared with control values. The binding of erythrocyte-antibody particles was found also to be normal. A depressed chemotactic activity of PMN cells against zymosan activated serum was also shown. The cause of the decreased chemotaxis of PMNs remains to be elucidated.
对20例进行性系统性硬化症（PSS）患者的多形核（PMN）中性粒细胞的体外功能进行了研究。发现外周血PMN的基础化学发光（CL）活性增加，提示这些细胞在体内已被预激活。皮肤疾病范围更广或有疾病进展迹象的患者往往具有更高的基础CL值。呼吸爆发期间的活性氧产物可能会增加炎症和纤维化过程的程度，并可能参与PSS中的内皮损伤。在我们的研究中，CL反应的刺激能力正常。与对照值相比，未发现粒细胞调理酵母吞噬活性有改变。还发现红细胞-抗体颗粒的结合正常。PMN细胞对酵母聚糖激活血清的趋化活性也降低。PMN趋化性降低的原因尚待阐明。
