被89Sr耗尽的骨髓依赖性细胞介导小鼠对1型单纯疱疹病毒感染的遗传抗性。
Marrow-dependent cells depleted by 89Sr mediate genetic resistance to herpes simplex virus type 1 infection in mice.
作者信息
Lopez C, Ryshke R, Bennett M
出版信息
Infect Immun. 1980 Jun;28(3):1028-32. doi: 10.1128/iai.28.3.1028-1032.1980.
Abstract
Adult mice resistant to infection with 10(6) plaque-forming units of a virulent strain of herpes simplex virus type 1 were treated with 89Sr to abrogate marrow-dependent cell functions. Treated mice were found to be much more susceptible to the herpes simplex virus type 1 infection than untreated mice. The virus persisted in the visceral tissues of 89Sr-treated mice for 3 or more days postinfection but not in those of untreated mice. The virus also spread to the spinal cords of treated but not untreated mice. A marrow-dependent cell appeared to mediate resistance to herpes simplex virus type 1 by controlling the infection early after inoculation and not allowing the infection spread to the central nervous system.
摘要
对10⁶个1型单纯疱疹病毒强毒株蚀斑形成单位感染具有抗性的成年小鼠，用⁸⁹Sr处理以消除骨髓依赖性细胞功能。结果发现，经处理的小鼠比未处理的小鼠对1型单纯疱疹病毒感染更易感。在感染后3天或更长时间，病毒持续存在于经⁸⁹Sr处理小鼠的内脏组织中，但未处理小鼠的内脏组织中则没有。病毒也扩散到经处理小鼠的脊髓，而未处理小鼠则未出现这种情况。一种骨髓依赖性细胞似乎通过在接种后早期控制感染，防止感染扩散到中枢神经系统，从而介导对1型单纯疱疹病毒的抗性。
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