Darby G, Larder B A, Bastow K F, Field H J
J Gen Virol. 1980 Jun;48(Pt 2):451-4. doi: 10.1099/0022-1317-48-2-451.
Vaccinia and pseudorabies viruses are resistant to ACV [Acyclovir or 9-(2-hydroxyethoxymethyl)guanine] in normal cells. However, both viruses are sensitive in thymidine kinase (TK)-transformed cells in which the resident HSV-specific TK is able to phosphorylate the drug. This demonstrates the sensitivity of these viruses to phosphorylated ACV and suggests a wider antiviral activity for the phosphorylated drug.
痘苗病毒和伪狂犬病病毒在正常细胞中对阿昔洛韦（ACV，即9-(2-羟乙氧甲基)鸟嘌呤）具有抗性。然而，这两种病毒在胸苷激酶（TK）转化的细胞中是敏感的，在这些细胞中，常驻的单纯疱疹病毒（HSV）特异性TK能够使该药物磷酸化。这证明了这些病毒对磷酸化阿昔洛韦的敏感性，并表明磷酸化药物具有更广泛的抗病毒活性。
