9-(2-羟乙氧甲基)鸟嘌呤对单纯疱疹病毒转化细胞的抗细胞作用。
Anticellular effects of 9-(2-hydroxyethoxymethyl) guanine against herpes simplex virus-transformed cells.
作者信息
Nishiyama Y, Rapp F
出版信息
J Gen Virol. 1979 Oct;45(1):227-30. doi: 10.1099/0022-1317-45-1-227.
PMID:230303
Abstract
The guanine derivative 9-(2-hydroxyethoxymethyl) guanine (acycloguanosine), a potent inhibitor of herpes simplex virus (HSV) multiplication, was found to have marked anticellular activity against HSV-transformed thymidine kinase-positive cells. HSV type I-transformed cells were more sensitive to the drug than HSV type 2-transformed cells.
摘要
鸟嘌呤衍生物9-(2-羟乙氧甲基)鸟嘌呤（无环鸟苷）是单纯疱疹病毒（HSV）增殖的强效抑制剂，已发现其对HSV转化的胸苷激酶阳性细胞具有显著的抗细胞活性。I型HSV转化的细胞比2型HSV转化的细胞对该药物更敏感。
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