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The identification and characterisation of chloramphenicol-aldehyde, a new human metabolite of chloramphenicol.

作者信息

Holt D E

机构信息

Karim Centre for Meningitis Research, Queen Charlotte's and Chelsea Hospital, London, UK.

出版信息

Eur J Drug Metab Pharmacokinet. 1995 Jan-Mar;20(1):35-42. doi: 10.1007/BF03192286.

DOI:10.1007/BF03192286
PMID:7588992
Abstract

The toxic aldehyde derivative of chloramphenicol has previously been reported as a metabolic product only in the rat. Chloramphenicol-aldehyde has been synthesised and characterised and shown to exist in at least two forms, possibly due to rearrangement within the molecule. The authenticated compound has been used to identify chloramphenicol-aldehyde as a metabolic product excreted in the urine of children treated with chloramphenicol.

摘要

相似文献

1
The identification and characterisation of chloramphenicol-aldehyde, a new human metabolite of chloramphenicol.
Eur J Drug Metab Pharmacokinet. 1995 Jan-Mar;20(1):35-42. doi: 10.1007/BF03192286.
2
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引用本文的文献

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Electrochemical Sensors for Chloramphenicol: Advances in Food Safety and Environmental Monitoring.用于氯霉素的电化学传感器：食品安全与环境监测进展
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本文引用的文献

1
Chloramphenicol toxicity.氯霉素毒性。
Adverse Drug React Toxicol Rev. 1993 Summer;12(2):83-95.
2
Bone marrow toxicity in vitro of chloramphenicol and its metabolites.氯霉素及其代谢产物的体外骨髓毒性。
Toxicol Appl Pharmacol. 1982 Jul;64(3):557-65. doi: 10.1016/0041-008x(82)90253-8.
3
Dimethoxyethylphthalate metabolism: teratogenicity of the diester and its metabolites in the pregnant rat.邻苯二甲酸二甲氧基乙酯的代谢：该二酯及其代谢产物对怀孕大鼠的致畸性
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4
The teratogenicity of methoxyacetic acid in the rat.甲氧基乙酸对大鼠的致畸性。
Toxicol Lett. 1984 Jul;22(1):93-100. doi: 10.1016/0378-4274(84)90051-1.
5
Mechanism of glutathione-dependent dechlorination of chloramphenicol and thiamphenicol by cytosol of rat liver.大鼠肝脏胞质溶胶对氯霉素和甲砜霉素进行谷胱甘肽依赖性脱氯作用的机制
Drug Metab Dispos. 1980 Nov-Dec;8(6):371-5.
6
Glutathione-dependent dechlorination of chloramphenicol by cytosol of rat liver.大鼠肝脏胞质溶胶对氯霉素的谷胱甘肽依赖性脱氯作用。
Drug Metab Dispos. 1980 Mar-Apr;8(2):93-7.
7
Preparation of trimethylsilyl derivates of chloramphenicol for gas-liquid chromatography.用于气液色谱分析的氯霉素三甲基硅烷衍生物的制备
J Chromatogr. 1973 Aug 1;82(2):297-306. doi: 10.1016/s0021-9673(01)91834-5.
8
Chloramphenicol: relation of structure to activity and toxicity.氯霉素：结构与活性及毒性的关系。
Annu Rev Pharmacol Toxicol. 1988;28:83-100. doi: 10.1146/annurev.pa.28.040188.000503.
9
Gas chromatographic determination and gas chromatographic-mass sepectrometric analysis of chloramphenicol, thiamphenicol and their metabolites.
J Chromatogr. 1975 Sep 3;111(2):355-64. doi: 10.1016/s0021-9673(00)99285-9.