Kapadia G J, Chung E B, Ghosh B, Shukla Y N, Basak S P, Morton J F, Pradhan S N
J Natl Cancer Inst. 1978 Mar;60(3):683-6. doi: 10.1093/jnci/60.3.683.
Twelve medicinal herbs were bioassayed to correlate a high incidence of esophageal carcinoma in natives of different places with their habitual consumption of these products. Outbred NIH Black rats were given 72 weekly sc injections of the total aqueous extracts of the plant materials. The tanninrich plant extracts from Areca catechu and Rhus copallina produced local tumors in 100 and 33%, respectively, of the experimental animals. Other materials included Diospyros virginiana and extracts from plants not rich in tannins. Diospyros and extracts of Sassafras albidum and Chenopodium ambrosiodes were tumorigenic in over 50% of the treated animals.
对12种药草进行了生物测定，以关联不同地区当地人食管癌的高发病率与其对这些产品的习惯性消费。将远交系NIH黑色大鼠每周皮下注射72次植物材料的总水提取物。槟榔和盐肤木富含单宁的植物提取物分别在100%和33%的实验动物中产生了局部肿瘤。其他材料包括美洲柿以及不含丰富单宁的植物提取物。美洲柿、北美檫木和土荆芥的提取物在超过50%的受试动物中具有致瘤性。
