Wenke G, Brunnemann K D, Hoffmann D, Bhide S V
J Cancer Res Clin Oncol. 1984;108(1):110-3. doi: 10.1007/BF00390981.
Betel quid chewing is strongly associated with cancer of the oral cavity, especially when tobacco is added to the quid. It is our working hypothesis that, during chewing, Areca-derived N-nitrosamines are formed and, in the presence of tobacco, Nicotiana-specific N-nitrosamines are formed as well and further that these agents may contribute to the high risk of oral cancer in betel-quid chewers. This preliminary report presents our finding of N-nitrosoguvacoline in the saliva of betel-quid chewers (2.2-350 ppb). When the quid contains tobacco, the tobacco-specific N-nitrosamines, N'-nitrosonornicotine (1.2-38.3 ppb), N'-nitrosoanatabine (3.2-39.5 ppb), and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (1.0-2.3 ppb) are also found in the saliva.
嚼食槟榔与口腔癌密切相关，尤其是在槟榔中添加烟草时。我们的工作假设是，在咀嚼过程中，槟榔会产生N-亚硝胺，并且在有烟草存在的情况下，烟草特有的N-亚硝胺也会形成，而且这些物质可能是导致嚼食槟榔者患口腔癌风险高的原因。这份初步报告展示了我们在嚼食槟榔者唾液中发现的N-亚硝基古豆碱（2.2 - 350 ppb）。当槟榔中含有烟草时，唾液中还会发现烟草特有的N-亚硝胺，如N'-亚硝基降烟碱（1.2 - 38.3 ppb）、N'-亚硝基新烟草碱（3.2 - 39.5 ppb）和4-(甲基亚硝胺基)-1-(3-吡啶基)-1-丁酮（1.0 - 2.3 ppb）。
