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槟榔和蒌叶的致癌性检测

Carcinogenicity examination of betel nuts and piper betel leaves.

作者信息

Mori H, Matsubara N, Ushimaru Y, Hirono I

出版信息

Experientia. 1979 Mar 15;35(3):384-5. doi: 10.1007/BF01964368.

DOI:10.1007/BF01964368
PMID:446629
Abstract

A dry powder of betel nuts, piper betel leaves and lime was administered to rats. Epidermal thickening was frequently observed in the upper digestive tracts of rats in groups fed the betel nut diet mixed with lime and the betel leaves diet, and a forestomach papilloma was seen in 1 rat given betel leaves diet. These epidermal changes were scarcely seen in rats given either betel nut or normal diet alone.

摘要

将槟榔、蒌叶和石灰的干粉喂给大鼠。在喂食含石灰的槟榔饮食和蒌叶饮食的大鼠组的上消化道中经常观察到表皮增厚,在1只喂食蒌叶饮食的大鼠中发现了前胃乳头状瘤。在单独喂食槟榔或正常饮食的大鼠中几乎看不到这些表皮变化。

相似文献

1
Carcinogenicity examination of betel nuts and piper betel leaves.槟榔和蒌叶的致癌性检测
Experientia. 1979 Mar 15;35(3):384-5. doi: 10.1007/BF01964368.
2
Carcinogenicity examination of betel quid. II. Effect of vitamin A deficiency on rats fed semipurified diet containing betel nut and calcium hydroxide.槟榔致癌性研究。II. 维生素A缺乏对喂食含槟榔和氢氧化钙半纯化日粮大鼠的影响。
Nutr Cancer. 1983;4(4):260-6. doi: 10.1080/01635588209513766.
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Carcinogenicity of betel quid. III. Enhancement of 4-nitroquinoline-1-oxide- and N-2-fluorenylacetamide-induced carcinogenesis in rats by subsequent administration of betel nut.槟榔的致癌性。III. 后续给予槟榔对4-硝基喹啉-1-氧化物和N-2-芴基乙酰胺诱导的大鼠致癌作用的增强。
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Experimental studies on betel nut and tobacco carcinogenicity.槟榔与烟草致癌性的实验研究。
Int J Cancer. 1976 Apr 15;17(4):469-76. doi: 10.1002/ijc.2910170409.
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Studies on the pathological effects of feeding betel-nut meal in albino rats.关于给白化大鼠喂食槟榔粕的病理影响的研究。
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Elevated frequency of micronucleated cells in the buccal mucosa of individuals at high risk for oral cancer: betel quid chewers.口腔癌高危人群(嚼槟榔者)颊黏膜微核细胞频率升高
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Fate of betel nut chemical constituents following nut treatment prior to chewing and its relation to oral precancerous & cancerous lesion.咀嚼前槟榔处理后槟榔化学成分的命运及其与口腔癌前病变和癌性病变的关系。
Dent J Malays. 1988 May;10(1):33-7.
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Long-term feeding study in C17 mice administered saccharin coated betel nut and 1,4-dinitrosopiperazine in combination.对C17小鼠进行长期喂养研究,使其同时摄入糖精包衣槟榔和1,4-二亚硝基哌嗪。
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Piper betel Linn (betel vine), the maligned Southeast Asian medicinal plant possesses cancer preventive effects: time to reconsider the wronged opinion.蒌叶(Piper betel Linn),这种被误解的东南亚药用植物具有防癌作用:是时候重新审视这一被冤枉的观点了。
Asian Pac J Cancer Prev. 2011;12(9):2149-56.
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Carcinogenicity of betel quid ingredients: feeding mice with aqueous extract and the polyphenol fraction of betel nut.槟榔咀嚼物成分的致癌性:用槟榔果水提取物和多酚组分喂养小鼠。
Br J Cancer. 1979 Dec;40(6):922-6. doi: 10.1038/bjc.1979.286.

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2
Studies on the pathological effects of feeding betel-nut meal in albino rats.关于给白化大鼠喂食槟榔粕的病理影响的研究。
Br J Exp Pathol. 1983 Oct;64(5):515-7.

本文引用的文献

1
ORAL CANCER IN NEW GUINEA. A STUDY IN DEMOGRAPHY AND ETIOLOGY.新几内亚的口腔癌。人口统计学与病因学研究。
Cancer. 1964 Oct;17:1289-98. doi: 10.1002/1097-0142(196410)17:10<1289::aid-cncr2820171011>3.0.co;2-e.
2
Betel, tobacco, and cancer of the mouth.槟榔、烟草与口腔癌。
Br J Cancer. 1960 Dec;14(4):597-608. doi: 10.1038/bjc.1960.65.
3
Betel cancer in Malaya.马来亚的槟榔癌
Med J Malaya. 1960 Mar;14:162-5.
4
Epithelial atypia in hamster cheek pouches treated repeatedly with calcium hydroxide.用氢氧化钙反复处理的仓鼠颊囊上皮异型增生。
Br J Cancer. 1966 Sep;20(3):588-93. doi: 10.1038/bjc.1966.73.
5
Factors influencing oral and oropharyngeal cancers in India.影响印度口腔和口咽癌的因素。
Br J Cancer. 1965 Dec;19(4):642-60. doi: 10.1038/bjc.1965.80.
6
Experimental production of cancer with betel nut, tobacco and slaked lime mixture.用槟榔、烟草和熟石灰混合物进行癌症的实验性诱发
J Indian Med Assoc. 1967 Oct 1;49(7):315-8 passim.
7
Evaluation of cancer risk in tobacco chewers and smokers: an epidemiologic assessment.嚼烟者和吸烟者癌症风险评估:一项流行病学评估。
Cancer. 1971 Jul;28(1):244-52. doi: 10.1002/1097-0142(197107)28:1<244::aid-cncr2820280150>3.0.co;2-h.
8
Carcinogenic effect of a dimethyl sulphoxide extract of betel nut on the mucosa of the hamster buccal pouch.槟榔二甲亚砜提取物对仓鼠颊囊黏膜的致癌作用。
Nature. 1971 Apr 9;230(5293):383-4. doi: 10.1038/230383a0.
9
Experimental studies on betel nut and tobacco carcinogenicity.槟榔与烟草致癌性的实验研究。
Int J Cancer. 1976 Apr 15;17(4):469-76. doi: 10.1002/ijc.2910170409.
10
Carcinogenicity of some folk medicinal herbs in rats.某些民间药草对大鼠的致癌性
J Natl Cancer Inst. 1978 Mar;60(3):683-6. doi: 10.1093/jnci/60.3.683.