Kapadia G J, Paul B D, Chung E B, Ghosh B, Pradhan S N
J Natl Cancer Inst. 1976 Jul;57(1):207-9. doi: 10.1093/jnci/57.1.207.
In an attempt to correlate the high incidence of esophageal carcinoma in natives of certain places with their habit of using herbaceous folk medicines, we performed bioassays of several plant extracts and the fractions prepared from them. Fourteen extracts and fractions from 6 plants were injected sc into NIH Black rats. The tannin fractions from Quercus falcata pagodaefolia, Diospyros virginiana, and Camellia sinensis were very active and produced tumors at the injection site in 66% or more of the treated animals. Tannin fractions from 3 other plants and total aqueous extracts from 5 to 6 tested plants were also tumorigenic rats. The induced tumors were malignant fibrous histiocytomas similar, if not identical, to those encountered in humans. The experiment indicated a possibility of induction of tumor in man by the tested plant materials.
为了将某些地区当地人食管癌的高发病率与其使用草本民间药物的习惯联系起来，我们对几种植物提取物及其制备的馏分进行了生物测定。从6种植物中提取的14种提取物和馏分被皮下注射到NIH黑色大鼠体内。来自宝塔栎、北美柿和茶树的单宁馏分非常活跃，在66%或更多的受试动物的注射部位产生了肿瘤。其他3种植物的单宁馏分以及5至6种受试植物的总水提取物对大鼠也具有致瘤性。诱发的肿瘤是恶性纤维组织细胞瘤，即便与人类所患的不完全相同，也是相似的。该实验表明，受试植物材料有可能诱发人类肿瘤。
