马立克氏病病毒基因组在同步化的非生产性MKT-1细胞中的复制
Replication of the resident Marek's Disease virus genome in synchronized nonproducer MKT-1 cells.
作者信息
Lau R Y, Nonoyama M
出版信息
J Virol. 1980 Feb;33(2):912-4. doi: 10.1128/JVI.33.2.912-914.1980.
Abstract
MKT-1, a virus nonproducer lymphoblastoid cell line established from a Marek's disease tumor, was synchronized by double thymidine block to determine the sequence of events in the synthesis of cellular and latent marek's disease virus DNA. Cellular DNA synthesis was measured by incorporation of [3H]thymidine, whereas viral DNA synthesis was determined by DNA-DNA reassociation kinetics. The results of these studies indicate that the resident Marek's disease viral DNA in MKT-1 cells replicates during the early S phase of the cell cycle, before the onset of active cellular DNA synthesis. This observation is similar to that seen in the replication of resident Epstein-Barr virus DNA in synchronized Raji cells.
摘要
MKT-1是一种从马立克氏病肿瘤建立的不产生病毒的淋巴母细胞系，通过双胸苷阻断法进行同步化处理，以确定细胞和潜伏性马立克氏病病毒DNA合成过程中的事件顺序。细胞DNA合成通过[3H]胸苷掺入来测定，而病毒DNA合成则通过DNA-DNA重缔合动力学来确定。这些研究结果表明，MKT-1细胞中的常驻马立克氏病病毒DNA在细胞周期的早期S期复制，早于活跃的细胞DNA合成开始之前。这一观察结果与在同步化的Raji细胞中常驻爱泼斯坦-巴尔病毒DNA的复制情况相似。
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