Lampert I A, Catovsky D, Bergier N
Br J Haematol. 1978 Sep;40(1):65-77. doi: 10.1111/j.1365-2141.1978.tb03640.x.
The clinico-pathological features of 12 cases of malignant histiocytosis (histiocytic medullary reticulosis), aged 12-60 years, were studied. Special emphasis was put on the analysis of the haematological, cytological and histopathological findings of the disease. Bone marrow aspirates and biopsies from involved tissues (liver, lymph node, spleen and skin) were found best suited for establishing the diagnosis. Cytochemical and ultrastructural data support the concept that the neoplastic cells belong to the mononuclear-phagocyte system. Three untreated patients died in less than 6 months. Median survival of the nine treated patients was 1 year. Seven patients were treated with the combination chemotherapy CHOP and four achieved a complete remission. Three of them are alive and continue in unmaintained remission for more than 1 year, surviving so far for 18+ to 31+ months. Two cases showed evidence of CNS involvement, one during life and the other as a post-mortem finding. The differential diagnosis from other related or unrelated disorders and the possible aetiological factors responsible for the disease are discussed in detail.
对12例年龄在12至60岁之间的恶性组织细胞增多症（组织细胞性髓性网状细胞增多症）患者的临床病理特征进行了研究。重点对该疾病的血液学、细胞学和组织病理学检查结果进行了分析。发现受累组织（肝脏、淋巴结、脾脏和皮肤）的骨髓穿刺物和活检组织最适合用于确诊。细胞化学和超微结构数据支持肿瘤细胞属于单核吞噬细胞系统这一观点。3例未经治疗的患者在6个月内死亡。9例接受治疗的患者的中位生存期为1年。7例患者接受了CHOP联合化疗，4例实现了完全缓解。其中3例存活，在未维持缓解状态下已超过1年，目前存活时间为18 +至31 +个月。2例出现中枢神经系统受累迹象，1例在生前出现，另1例为尸检发现。详细讨论了与其他相关或不相关疾病的鉴别诊断以及该疾病可能的病因。
