Murray D, Wild G E
Can J Physiol Pharmacol. 1980 Jun;58(6):643-9. doi: 10.1139/y80-106.
The effect of fasting on mucosal Na-K-ATPase activity in various regions of rat small intestine was investigated. Fasting (17--48 h) was associated with a consistent decrease in specific and total activity of Na-K-ATPase in the jejunum, the levels tending to rise more distally. No effect on the specific activities of Mg-ATPase or alkaline phosphatase was found. Fasting was also associated with incresed adrenocortical activity and with decreases in mucosal mass, protein content, and histological dimensions of the jejunum, no similar changes being found in the distal small intestine. Glucose ingestion prevented the decrease in jejunal enzyme activity associated with fasting and elevated levels in the mid and terminal small intestine of fed animals. These effects suggest that Na-K-ATPase activity in small intestinal mucosa may be, in part, inducible.
研究了禁食对大鼠小肠各部位黏膜钠钾ATP酶活性的影响。禁食（17 - 48小时）与空肠中钠钾ATP酶的比活性和总活性持续下降有关，该水平在更靠近远端处有上升趋势。未发现对镁ATP酶或碱性磷酸酶的比活性有影响。禁食还与肾上腺皮质活性增加以及空肠黏膜质量、蛋白质含量和组织学尺寸减小有关，在远端小肠未发现类似变化。摄入葡萄糖可防止与禁食相关的空肠酶活性下降，并使喂食动物的小肠中部和末端水平升高。这些结果表明，小肠黏膜中的钠钾ATP酶活性可能部分是可诱导的。
