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破坏微管或微丝的因素会增加多瘤病毒导致细胞转化的频率。

Factors which disorganize microtubules or microfilaments increase the frequency of cell transformation by polyoma virus.

作者信息

Seif R

出版信息

J Virol. 1980 Nov;36(2):421-8. doi: 10.1128/JVI.36.2.421-428.1980.

DOI:10.1128/JVI.36.2.421-428.1980
PMID:6253667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC353658/
Abstract

Griseofulvin, 12-O-tetradecanoyl phorbol-13-acetate, melittin, epidermal growth factor, vinblastine, cytochalasin B, podophyllotoxin, colcemid, and colchicine were unable to transform cells but could increase from 8- to 40-fold the frequency of cell transformation by polyoma virus. The 3T3-like cells were resting at confluence and were exposed to the drug only during the 1st week after viral infection. Griseofulvin, a tumor promoter, reduced or increased the frequency of transformation depending on the dose with which the infected cells were treated. The antitumor activity of tumor promoters is discussed.

摘要

灰黄霉素、12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯、蜂毒肽、表皮生长因子、长春碱、细胞松弛素B、鬼臼毒素、秋水仙酰胺和秋水仙碱均无法诱导细胞转化，但可使多瘤病毒诱导的细胞转化频率提高8至40倍。3T3样细胞在汇合时处于静止状态，仅在病毒感染后的第1周接触药物。肿瘤促进剂灰黄霉素根据处理感染细胞的剂量不同，可降低或提高转化频率。文中讨论了肿瘤促进剂的抗肿瘤活性。

相似文献

1
Factors which disorganize microtubules or microfilaments increase the frequency of cell transformation by polyoma virus.破坏微管或微丝的因素会增加多瘤病毒导致细胞转化的频率。
J Virol. 1980 Nov;36(2):421-8. doi: 10.1128/JVI.36.2.421-428.1980.
2
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The effect of colchicine on the induction of ornithine decarboxylase by 12-O-tetradecanoyl-phorbol-13-acetate.秋水仙碱对12-O-十四烷酰佛波醇-13-乙酸酯诱导鸟氨酸脱羧酶的影响。
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Melittin shares certain cellular effects with phorbol ester tumour promoters.
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Succinyl concanavalin A stimulates and antimicrotubular drugs inhibit the synthesis of a brain-specific protein in rat glial cells.琥珀酰伴刀豆球蛋白A刺激而抗微管药物抑制大鼠神经胶质细胞中一种脑特异性蛋白质的合成。
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Effect of colchicine, vinblastine, and cytochalasin B on cell surface anionic sites of Tritrichomonas foetus.秋水仙碱、长春碱和细胞松弛素B对胎儿三毛滴虫细胞表面阴离子位点的影响。
J Protozool. 1986 Feb;33(1):6-10. doi: 10.1111/j.1550-7408.1986.tb05546.x.

引用本文的文献

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Melittin Increases Cisplatin Sensitivity and Kills KM-H2 and L-428 Hodgkin Lymphoma Cells.蜂毒肽可增强顺铂敏感性并杀死KM-H2和L-428霍奇金淋巴瘤细胞。
Int J Mol Sci. 2020 Dec 31;22(1):343. doi: 10.3390/ijms22010343.
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Generation of metastatic melanoma specific antibodies by affinity purification.通过亲和纯化生成转移性黑色素瘤特异性抗体。
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An armamentarium of wart treatments.一套疣治疗方法。
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本文引用的文献

1
Melittin shares certain cellular effects with phorbol ester tumour promoters.
Nature. 1979 Jul 5;280(5717):72-4. doi: 10.1038/280072a0.
2
ENHANCEMENT BY THYMIDINE ANALOGS OF SUSCEPTIBILITY OF CELLS TO TRANSFORMATION BY SV40.胸腺嘧啶类似物对细胞被SV40转化的敏感性的增强作用。
Virology. 1964 Nov;24:393-400. doi: 10.1016/0042-6822(64)90177-1.
3
EARLY CHROMOSOMAL CHANGES IN SV40-INFECTED HUMAN FIBROBLAST CULTURES.猴空泡病毒40感染的人成纤维细胞培养物中的早期染色体变化
Cytogenetics. 1964;3:45-61. doi: 10.1159/000129797.
4
EFFECT OF X-IRRADIATION ON SUSCEPTIBILITY OF CELLS TO TRANSFORMATION BY POLYOMA VIRUS.X射线照射对细胞被多瘤病毒转化的易感性的影响。
Nature. 1963 Nov 23;200:756-8. doi: 10.1038/200756a0.
5
THE VINCA ALKALOIDS: A NEW CLASS OF ONCOLYTIC AGENTS.长春花生物碱：一类新型溶瘤剂。
Cancer Res. 1963 Sep;23:1390-427.
6
Steps in the neoplastic transformation of hamster embryo cells by polyoma virus.多瘤病毒使仓鼠胚胎细胞发生肿瘤转化的步骤。
Proc Natl Acad Sci U S A. 1963 Feb 15;49(2):171-9. doi: 10.1073/pnas.49.2.171.
7
Oral griseofulvin: a cocarcinogenic agent to methylcholanthrene induced cutaneous tumors.口服灰黄霉素：对甲基胆蒽诱发的皮肤肿瘤具有促癌作用的一种物质。
Cancer Res. 1962 Jan;22:53-5.
8
Effect of cytoskeleton-disrupting agents on the metastatic behavior of melanoma cells.细胞骨架破坏剂对黑色素瘤细胞转移行为的影响。
J Natl Cancer Inst. 1980 Apr;64(4):891-900.
9
Polyoma virus middle t antigen: a tumor progression factor.多瘤病毒中T抗原：一种肿瘤进展因子。
J Virol. 1980 Aug;35(2):479-87. doi: 10.1128/JVI.35.2.479-487.1980.
10
SV40-induced somatic mutations: possible relevance to viral transformation.SV40诱导的体细胞突变：与病毒转化的可能关联。
Cold Spring Harb Symp Quant Biol. 1980;44 Pt 1,:377-82. doi: 10.1101/sqb.1980.044.01.042.