Fisher G L, Shifrine M
Oncology. 1978;35(1):22-5. doi: 10.1159/000225249.
Neoplastic growths seem to interfere with normal processes regulating the serum level of ceruloplasmin, a copper-containing oxidase, which accounts for 96% of serum copper. Normal catabolism of ceruloplasmin in the liver follows desialylation. However, in patients with tumors, ceruloplasmin may be resialylated at the tumor cell surface or in peripheral blood. Decreased catabolism due to resialylation of asialo-ceruloplasmin could account for the increased concentration of serum copper noted in patients with neoplasia.
肿瘤生长似乎会干扰调节血清铜蓝蛋白水平的正常过程，铜蓝蛋白是一种含铜氧化酶，占血清铜的96%。肝脏中铜蓝蛋白的正常分解代谢是在去唾液酸化之后进行的。然而，在肿瘤患者中，铜蓝蛋白可能在肿瘤细胞表面或外周血中重新被唾液酸化。脱唾液酸铜蓝蛋白重新被唾液酸化导致分解代谢减少，这可能是肿瘤患者血清铜浓度升高的原因。
