人类白细胞抗原相关的基因控制人类对腮腺炎病毒的T细胞介导的细胞毒性反应。
Human leukocyte antigen-linked genetic controls for T cell-mediated cytotoxic response to mumps virus in humans.
作者信息
Chiba Y, Tsutsumi H, Nakao T, Wakisaka A, Aizawa M
出版信息
Infect Immun. 1982 Feb;35(2):600-4. doi: 10.1128/iai.35.2.600-604.1982.
Abstract
The involvement of human leukocyte antigen determinants for the response of mumps virus-specific cytotoxic T lymphocytes in humans was studied. The cytotoxic T lymphocytes could only lyse virus-infected allogeneic cells with which they shared a particular human leukocyte antigen, e.g., Bw52 or B7. The existence of Bw52 in the subjects who received a booster immunization with live mumps vaccine was associated with a significantly higher cytotoxic T-lymphocyte response than that of subjects without the gene. Although a donor-dependent difference in the recognition of human leukocyte antigen-A2 suggests the complexity of the genetic mechanisms involved, the results are largely consistent with the concept of major histocompatibility complex-linked genetic control of virus-specific cytotoxic T-lymphocyte response.
摘要
对人类中腮腺炎病毒特异性细胞毒性T淋巴细胞反应的人类白细胞抗原决定簇的参与情况进行了研究。细胞毒性T淋巴细胞只能裂解与其共享特定人类白细胞抗原（例如Bw52或B7）的病毒感染的同种异体细胞。接受减毒活腮腺炎疫苗加强免疫的受试者中存在Bw52，与没有该基因的受试者相比，其细胞毒性T淋巴细胞反应显著更高。尽管在人类白细胞抗原-A2识别方面存在供体依赖性差异表明所涉及的遗传机制很复杂，但结果在很大程度上与主要组织相容性复合体相关的病毒特异性细胞毒性T淋巴细胞反应的遗传控制概念一致。
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本文引用的文献
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