Cho-Chung Y S
J Cyclic Nucleotide Res. 1980;6(3):163-77.
A working hypothesis is presented to elucidate the action of cyclic AMP in the regulation of tumor growth in vivo. The formation and nuclear translocation of a complex consisting of cyclic AMP, its receptor binding protein, and the catalytic unit of protein kinase are the indispensable events necessary to trigger the regression of hormone-dependent mammary tumors. If the integrity of the cyclic AMP receptor molecule is not preserved and the cyclic AMP concentration is not physiological, the above processes do not occur and tumors remain hormone-unresponsive. It is therefore postulated that arrest of tumor growth in vivo depends upon the structural integrity of the cyclic AMP receptor protein and the optimum cellular concentration of cyclic AMP, which make possible the formation and nuclear translocation of the cyclic AMP receptor complex.
提出了一个工作假设，以阐明环磷酸腺苷（cAMP）在体内肿瘤生长调节中的作用。由环磷酸腺苷、其受体结合蛋白和蛋白激酶催化单元组成的复合物的形成及核转位是触发激素依赖性乳腺肿瘤消退所必需的不可或缺的事件。如果环磷酸腺苷受体分子的完整性未得到保持且环磷酸腺苷浓度不符合生理水平，上述过程就不会发生，肿瘤仍对激素无反应。因此推测，体内肿瘤生长的停滞取决于环磷酸腺苷受体蛋白的结构完整性和环磷酸腺苷的最佳细胞浓度，这使得环磷酸腺苷受体复合物的形成及核转位成为可能。
