Berjian R A, Douglass H O, Nava H R, Karakousis C
J Surg Oncol. 1980;14(4):379-87. doi: 10.1002/jso.2930140412.
Because of limited benefits derived with the use of systemic chemotherapy, 15 patients with metastatic malignancy of the liver or hepatoma were treated by hepatic artery ligation (6) or dearterialization (9) and regional infusion chemotherapy. There were two postoperative deaths and three patients required surgical drainage of hepatic tumor liquefaction necrosis. The median survival was 14 months with two patients still living. The longest survivors were those patients with visceral leiomyosarcoma or carcinoid tumor. Five of the patients had failed to respond to previous chemotherapy, all showed a favorable response to this therapy. Rigid criteria for proper case selection have been developed which should reduce the operative mortality. Hepatic artery ligation is a therapeutic modality that can be of benefit to patients for whom no other satisfactory treatment is available.
由于全身化疗的益处有限，15例肝转移性恶性肿瘤或肝癌患者接受了肝动脉结扎术（6例）或去动脉化术（9例）及区域灌注化疗。术后有2例死亡，3例患者需要对肝肿瘤液化坏死进行手术引流。中位生存期为14个月，仍有2例患者存活。存活时间最长的是那些患有内脏平滑肌肉瘤或类癌肿瘤的患者。其中5例患者对先前的化疗无反应，而对本治疗均显示出良好反应。已制定了严格的合适病例选择标准，这应能降低手术死亡率。肝动脉结扎术是一种治疗方式，对于没有其他满意治疗方法的患者可能有益。
