Miller B J, Wright J L, Colquhoun B P
Surg Gynecol Obstet. 1978 Mar;146(3):412-4.
Since 1955, 33 patients with actinomycosis were treated at the University Hospital, Saskatoon, Sixty-seven per cent of the lesions involved the cervicofacial region; 24 per cent, the abdomen, and 9 per cent, the thorax. Trauma, inflammation or immunosuppression may have been partly responsible for the infection in 14 of the patients. Follow-up data were available for 21 patients. One of these patients died of thoracic actinomycosis, having received immunosuppressive therapy for leukemia. The others progressed well after treatment. In one patient with intra-abdominal actinomycosis, the disease was confined to the greater omentum and was apparently unrelated to the gastrointestinal or genitourinary tracts. He recovered after excision of the greater omentum and large dosages of penicillin. A search of the literature reveals that other reports on seemingly isolated intra-abdominal actinomycosis describe disease adjacent to hollow organs which required their removal. Immunologic studies demonstrated that a saline suspension of Actinomyces israelii was capable of inhibiting phytohemagglutinin stimulation of both the lymphocytes of the patient and of those of three normal donors. This may play a part in the progression of the disease.
自1955年以来，萨斯卡通市大学医院共治疗了33例放线菌病患者。67%的病变累及头颈部区域；24%累及腹部，9%累及胸部。14例患者的感染可能部分归因于创伤、炎症或免疫抑制。21例患者有随访数据。其中1例因白血病接受免疫抑制治疗，死于胸段放线菌病。其他患者治疗后恢复良好。1例腹内放线菌病患者，疾病局限于大网膜，显然与胃肠道或泌尿生殖道无关。切除大网膜并大剂量使用青霉素后，他康复了。文献检索显示，其他关于看似孤立的腹内放线菌病的报告描述了与中空器官相邻的疾病，这些疾病需要切除相关器官。免疫学研究表明，以色列放线菌的生理盐水悬液能够抑制植物血凝素对患者淋巴细胞以及三名正常供体淋巴细胞的刺激。这可能在疾病进展中起作用。
