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促肾上腺皮质激素4-9类似物作用后的Y迷宫行为,提示注意力改变

Y-maze behavior after an analog of ACTH 4--9, evidence for an attentional alteration.

作者信息

Katz R J, Chudler R

出版信息

Psychopharmacology (Berl). 1980;71(1):95-6. doi: 10.1007/BF00433260.

Abstract

Adult, male, Swiss-Webster mice were injected with either control solution or various doses of a long-acting analog of ACTH 4--9. The drug produced significant alterations in performance in an equiangular Y-maze. In comparison with control performance, both 25 and 50 micrograms/kg of drug produced a significant increase in repeated two-arm entries. This response pattern is consistent with the hypothesis that the drug produced a focusing of attention.

摘要

成年雄性瑞士韦伯斯特小鼠被注射了对照溶液或不同剂量的促肾上腺皮质激素4-9长效类似物。该药物在等角Y迷宫实验中使行为表现发生了显著变化。与对照表现相比,25微克/千克和50微克/千克的药物剂量均使双臂重复进入次数显著增加。这种反应模式与该药物引起注意力集中的假说相一致。

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