Friedman M A, Hoffman P G, Dandolos E M, Lagios M D, Johnston W H, Siiteri P K
Cancer. 1981 Jan 1;47(1):134-7. doi: 10.1002/1097-0142(19810101)47:1<134::aid-cncr2820470122>3.0.co;2-m.
Breast cancer tissue from 12 male patients was evaluated for the presence of estrogen receptors (ER), and at least 10 of 12 were found to be high in ER (ER+). A combination of previously published cases and our own experience indicates that 80% of patients (37/47) have ER+ tumors. This incidence of ER positivity in men is greater than that in women with breast cancer. Clinical responses to hormonal therapy have been observed in the ER+ patients but not in one ER--patient. Measurement of ER may be clinically important in men with breast cancer.
对12例男性患者的乳腺癌组织进行雌激素受体（ER）检测，发现12例中至少10例ER水平较高（ER阳性）。结合既往已发表的病例及我们自己的经验表明，80%的患者（37/47）肿瘤为ER阳性。男性患者中ER阳性的发生率高于女性乳腺癌患者。在ER阳性患者中观察到了对激素治疗的临床反应，但1例ER阴性患者未出现反应。对于男性乳腺癌患者，检测ER可能具有重要的临床意义。
