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[根据电子顺磁共振自旋探针研究结果探讨高α脂蛋白血症对血浆脂蛋白结构特征的影响]

[Effect of hyperalphalipoproteinemia on structural characteristics of plasma lipoproteins according to electron paramagnetic resonance spin probe findings].

作者信息

Torkhovskaia T I, Artemova L G, Shcherbakova I A, Suchkova S N, Zadoia A A

出版信息

Biull Eksp Biol Med. 1980 Dec;90(12):694-6.

PMID:6258668
Abstract

Spin probe, a stearic acid derivative, was used to study the structural features of different lipoproteins (LP) from plasma of subjects with different plasma level of high density LP (HDLP). Access of spin probe located in the internal nonpolar regions of HDLP for the reducer, ascorbic acid, was higher in hyperalphalipoproteinemia than in mean values of HDLP cholesterol concentration. An analogous effect was seen in subjects with LP of very low density. Possible causes of such differences as well as their role in biochemical reactions that proceed with LP participation are discussed.

摘要

自旋探针是一种硬脂酸衍生物,用于研究来自不同高密度脂蛋白(HDLP)血浆水平受试者血浆中不同脂蛋白(LP)的结构特征。在高α脂蛋白血症中,位于HDLP内部非极性区域的自旋探针对还原剂抗坏血酸的可及性高于HDLP胆固醇浓度的平均值。在极低密度脂蛋白的受试者中也观察到类似的效果。讨论了这种差异的可能原因及其在脂蛋白参与的生化反应中的作用。

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