Kerimov T M, Perova N V, Suchkova S N, Shcherbakova I A, Gerasimova E N
Vopr Med Khim. 1978 Jul-Aug;24(4):559-66.
Lipoprotein structure was studied by means of EPR-spectroscopy of spin probes--iminoxyl derivatives of stearic acid and of androstane--in blood plasma of 40-59 years old men. The mode of wrapping of external monolayer of lipoprotein particles, the type of their intermolecular interactions were similar to corresponding characteristics of bilayer in biological and model membranes. Correlation was observed between concentration of separate lipoproteins in blood plasma and the structural parameters of the probe distribution in hydrophobic and polar regions of the lipoprotein preparations. The phenomena observed might be related to capacity of the high density lipoproteins to accept cholesterol from cell membranes with transfer of cholesterol into liver tissue, where it is subsequently metabolized, as well as to the property of the very low density lipoproteins to transfer cholesterol into tissues, particularly, into vascular walls.
通过电子顺磁共振光谱法（EPR）对40至59岁男性血浆中的自旋探针——硬脂酸和雄甾烷的异亚硝基氧衍生物进行研究，以探讨脂蛋白结构。脂蛋白颗粒外层单层的包裹模式及其分子间相互作用类型与生物膜和模型膜中双层的相应特征相似。观察到血浆中各脂蛋白浓度与脂蛋白制剂疏水和极性区域中探针分布的结构参数之间存在相关性。所观察到的现象可能与高密度脂蛋白从细胞膜接受胆固醇并将胆固醇转运至肝脏组织（随后在肝脏组织中进行代谢）的能力有关，也与极低密度脂蛋白将胆固醇转运至组织（特别是血管壁）的特性有关。
