Zasukhina G D, Krasovskiĭ G N, Vasil'eva I M, Sdirkova N I, Sokolvskiĭ V V
Biull Eksp Biol Med. 1980 Dec;90(12):723-5.
The action of thallium carbonate (Tl2CO3) on rat embryonic cells was evaluated in accordance with the criterion for the formation of DNA breaks and chromosome aberrations, survival and mutagenicity of smallpox vaccine virus in these cells and on the basis of the frequency of dominant mutations in rats. Tl2CO3 produces DNA breaks whose restoration during 24 hours postincubation depends on the agent concentration. As the survival of smallpox vaccine virus exposed to Tl2CO3 decreases by a factor of 10(1) the virus mutagenicity rises 3fold. Tl2CO3 also possesses marked mutagenic activity as measured from the formation of chromosome aberrations. In the course of Tl2CO3 poisoning of males (for 8 months), followed by mating with intact females, there was a tendency to the increased total embryonic lethiality.
根据DNA断裂和染色体畸变的形成标准、天花疫苗病毒在这些细胞中的存活和致突变性以及大鼠显性突变频率，评估了碳酸铊（Tl2CO3）对大鼠胚胎细胞的作用。Tl2CO3会产生DNA断裂，孵育后24小时内其修复情况取决于试剂浓度。随着暴露于Tl2CO3的天花疫苗病毒存活率降低10倍，病毒致突变性增加3倍。从染色体畸变的形成情况来看，Tl2CO3也具有显著的致突变活性。在雄性大鼠经Tl2CO3中毒8个月后，再与未接触该物质的雌性大鼠交配，胚胎总致死率有增加的趋势。
