Zasukhina G D, Vasilyeva I M, Sdirkova N I, Krasovsky G N, Kenesariev U I, Butenko P G
Mutat Res. 1983 Nov;124(2):163-73. doi: 10.1016/0165-1218(83)90176-3.
The mutagenic activity of thallium carbonate and mercury chloride was estimated by the HAP chromatography and virus reactivation methods in cultures of embryo cells of mice (CBA and C57Bl/6 strains) and rats and by the dominant mutation frequency in rats. Thallium carbonate induced single-stranded DNA breaks. The induction of DNA breaks correlated with the rate of virus reactivation and the mutability of vaccinia virus in the cell cultures studied. DNA breaks in experiments with mercury chloride occurred at much lower concentrations as compared with these of thallium carbonate. The rate of vaccinia virus reactivation in cells treated with mercury chloride was reduced, whereas the level of virus mutagenesis did not differ from the control. In the dominant lethal test the mutagenic activity of thallium carbonate was higher than the mutagenic activity of mercury chloride.
采用高效液相色谱法和病毒复活法，通过对小鼠（CBA和C57Bl/6品系）和大鼠胚胎细胞培养物进行检测，并利用大鼠的显性突变频率，对碳酸铊和氯化汞的诱变活性进行了评估。碳酸铊可诱导单链DNA断裂。在所研究的细胞培养物中，DNA断裂的诱导与病毒复活率以及痘苗病毒的变异性相关。与碳酸铊相比，氯化汞实验中DNA断裂发生的浓度要低得多。用氯化汞处理的细胞中痘苗病毒复活率降低，而病毒诱变水平与对照组无差异。在显性致死试验中，碳酸铊的诱变活性高于氯化汞的诱变活性。
