Pawlicka E, Bańkowski E, Pałka J, Markiewicz W
Department of Biochemistry, Medical Academy of Białystok, Poland.
Hepatogastroenterology. 1987 Dec;34(6):243-5.
It was found that chronic intoxication of rats with ethanol results in an increase in prolyl hydroxylase activity in liver and serum of the investigated animals. Similar effects have been observed in some alcoholic patients. We hope that the assay of prolyl hydroxylase in serum or in liver biopsy samples might be useful for the diagnosis and prognosis of the tendency of some individuals to develop liver cirrhosis.
研究发现，用乙醇对大鼠进行慢性中毒会导致被调查动物肝脏和血清中的脯氨酰羟化酶活性增加。在一些酗酒患者中也观察到了类似的效果。我们希望，检测血清或肝活检样本中的脯氨酰羟化酶可能有助于诊断和预测某些个体发生肝硬化的倾向。
