一种辐射防护剂对卡那霉素诱导的耳毒性的预防作用
Prophylaxis of kanamycin-induced ototoxicity by a radioprotectant.
作者信息
Pierson M G, Møller A R
出版信息
Hear Res. 1981 Mar;4(1):79-87. doi: 10.1016/0378-5955(81)90037-x.
PMID:6259113
Abstract
S-2 (3-aminopropylamino)ethylphosphorothioate ameliorates hearing losses due to ototoxic doses of kanamycin sulfate in the guinea pig when administered one hour before the antibiotic. Since this radioprotectant is believed to operate as a free-radical scavenger, kanamycin ototoxicity may involve free radicals.
摘要
S-2（3-氨丙基氨基）乙基硫代磷酸酯在豚鼠使用硫酸卡那霉素耳毒性剂量前1小时给药时，可改善由其导致的听力损失。由于这种辐射防护剂被认为作为自由基清除剂发挥作用，卡那霉素耳毒性可能涉及自由基。
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