Mal'chikova L S, Elizarova E P
Kardiologiia. 1981 Jan;21(1):85-9.
The mechanism of the decrease in the heart of cAMP content under the effect of taurine was studied. It was shown on a preparation of cytoplasmic membranes isolated from the rat heart that under the effect of taurine (10(-6)--10(-3) M) the activity of phosphodiesterase and adenylate cyclase increases to the maximum by 2.4 and 1.4 times, respectively. Taurine weakens the activation of adenylate cyclase by adrenaline. The effect of taurine on adenylate cyclase activity diminishes under the action of phentolamine and obsidan and is practically not manifested in the simultaneous presence of both adrenoblocking agents. Taurine obviously changes the content of cAMP in the heart by altering the activity of adenylate cyclase and phosphodiesterase.
研究了牛磺酸作用下心脏中cAMP含量降低的机制。在从大鼠心脏分离的细胞质膜制剂上显示，在牛磺酸（10⁻⁶ - 10⁻³ M）作用下，磷酸二酯酶和腺苷酸环化酶的活性分别增加至最大值的2.4倍和1.4倍。牛磺酸减弱了肾上腺素对腺苷酸环化酶的激活作用。在酚妥拉明和育亨宾作用下，牛磺酸对腺苷酸环化酶活性的影响减弱，而在两种肾上腺素阻断剂同时存在时几乎不表现出来。牛磺酸显然通过改变腺苷酸环化酶和磷酸二酯酶的活性来改变心脏中cAMP的含量。
