Motovski A, Veselinova A, Shalamanov D
Vet Med Nauki. 1980;17(4):23-9.
An experiment was carried out on 125 pigs, originating from immune mothers on an enzootic for A. D. swine-breeding farm. The pigs were vaccinated once and twice with living vaccine MK-25 at different moments after their weaning. On the 180th after the vaccination the pigs were infected with a virulent (10(6) TCID) pseudorabies virus. They were studied clinically, serologically, virologically and pathomorphologically. It was proved that the vaccination of pigs, born by immune mothers, did not bring about the formation of a solid active immunity due to the neutralization of the vaccinal virus by the colostral immunity. A later vaccination of the pigs after the exhaustion of colostral immunity, did not lead to an increased vaccination effect, since during that period met with the persistent virus on the enzootic farm. Re-vaccination, however, created resistance of pigs to infection and a limited persistence of virulent virus.
在一个发生猪伪狂犬病地方流行的养猪场,对125头来自免疫母猪的仔猪进行了一项实验。这些仔猪在断奶后的不同时间,分别接种了一次和两次MK - 25活疫苗。接种后第180天,用强毒(10⁶TCID)伪狂犬病病毒感染这些仔猪。对它们进行了临床、血清学、病毒学和病理形态学研究。结果证明,由于初乳免疫中和了疫苗病毒,来自免疫母猪的仔猪接种疫苗后并未形成牢固的主动免疫。初乳免疫耗尽后对仔猪进行后期接种,并未提高接种效果,因为在此期间地方流行猪场存在持续性病毒。然而,再次接种可使仔猪产生抗感染能力,并使强毒病毒的持续时间有限。