Cutlip R C, McClurkin A W, Coria M F
Am J Vet Res. 1980 Dec;41(12):1938-41.
Four clinically healthy cattle persistently infected with the virus of bovine viral diarrhea were examined for viral antigen and lesions. Antigen was seen by direct immunofluorescence in cytoplasm of the neurons of the brain and cervical part of the spinal cord, cells and basement membrane of renal glomeruli, reticular cells of lymph nodes and spleen, epithelial cells of small intestinal crypts and renal and testicular tubules, and endothelial cells of blood vessels. Infected neurons were pyknotic and surrounded by astrocytes and macrophages. A few blood vessels in the brains were cuffed with mononuclear cells. Basement membranes of renal glomeruli were irregularly thick with eosinophilic material, and mesangial cells in the glomeruli were plentiful. The virus had a direct effect on some tissues, but was restricted in its cytopathogenicity and was not eliminated by defense mechanisms of the host. Renal glomerular lesions were believed to have an immunologic basis.
对4头持续感染牛病毒性腹泻病毒的临床健康牛进行了病毒抗原和病变检查。通过直接免疫荧光法在脑和脊髓颈部神经元的细胞质、肾小球的细胞和基底膜、淋巴结和脾脏的网状细胞、小肠隐窝以及肾和睾丸小管的上皮细胞以及血管内皮细胞中发现了抗原。受感染的神经元固缩，周围有星形胶质细胞和巨噬细胞。脑内少数血管有单核细胞套袖现象。肾小球基底膜不规则增厚，有嗜酸性物质，肾小球系膜细胞丰富。该病毒对某些组织有直接作用，但其细胞致病性受到限制，且未被宿主的防御机制清除。肾小球病变被认为有免疫基础。
