Zimmer A M, Spies S M
J Nucl Med. 1981 May;22(5):465-7.
We have developed a simplified, semiquantitative test for the determination of stannous tin in pyrophosphate and other tin-containing radiopharmaceuticals, excluding those stabilized with ascorbic acid and MAA preparations. The test involves the formation and disappearance of a positive red color complex in the presence of Sn(II) and in acidified porphyrin solution. With this technique, the time of spot disappearance is directly proportional to the Sn(II) concentration spotted. The procedure is easy to use, requiring only a high-intensity light source (30-watt light bulb) and a timing device. The test is accurate, reproducible, and sensitive to Sn(II) levels as low as 40 micrograms/ml. Because the procedure is rapid (requiring less than 5 min), it can easily be incorporated into the routine radiopharmaceutical quality-control program of any nuclear medicine facility.
我们已开发出一种简化的半定量测试方法，用于测定焦磷酸盐及其他含锡放射性药物中的亚锡，不包括用抗坏血酸稳定的药物和MAA制剂。该测试涉及在Sn(II)存在下以及在酸化的卟啉溶液中形成和消失阳性红色络合物。采用这种技术，斑点消失的时间与点样的Sn(II)浓度成正比。该方法易于使用，仅需一个高强度光源（30瓦灯泡）和一个计时装置。该测试准确、可重复，对低至40微克/毫升的Sn(II)水平敏感。由于该方法快速（耗时不到5分钟），它可轻松纳入任何核医学设施的常规放射性药物质量控制程序。
