Chabasse D, Oriot M, Larra F
Sem Hop. 1981;57(7-8):373-8.
The study of 186 cases (bed rests) of patients who have had a therapeutical radiotherapy shows that: those who have received a thoracic irradiation (neo-breast) do not release an appreciable hypereosinophilia (2% of cases); those who have received a pelvic irradiation (neo uterus, testicle, ovary) set a mode-rate hypereosinophilia (from 450 to 1 000 eosino/mm3) in 90% of cases; in Hodgkin's disease, 15% of the patients have an hypereosinophilia before any treatment; it increases to 34% after radiotherapy (cobalt 60); No difference has been shown either with the site of radiation (up or under the diaphragmatic) or with the age of the patients. On the other hand, a significative prognosis (survival greater than or equal to 5 years). From these observations, the authors propose some physiopathological hypothesis on the signification of hypereosinophilia in the course of therapeutical irradiations and Hodgkin's disease.
对186例接受过放射治疗的患者(卧床休息)的研究表明:接受胸部照射(新乳房)的患者未出现明显的嗜酸性粒细胞增多(2%的病例);接受盆腔照射(新子宫、睾丸、卵巢)的患者90%出现中度嗜酸性粒细胞增多(450至1000个嗜酸性粒细胞/立方毫米);在霍奇金病中,15%的患者在任何治疗前就有嗜酸性粒细胞增多;放疗(钴60)后增至34%;无论是放疗部位(膈肌上方或下方)还是患者年龄,均未显示出差异。另一方面,有显著的预后(生存期大于或等于5年)。基于这些观察结果,作者提出了一些关于治疗性照射和霍奇金病过程中嗜酸性粒细胞增多意义的生理病理假设。