• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在其他药理学试验中为激动剂的苯并吗啡烷类药物在大鼠输精管中出现意外的拮抗作用。

Unexpected antagonism in the rat vas deferens by benzomorphans which are agonists in other pharmacological tests.

作者信息

Gillan M G, Kosterlitz H W, Magnan J

出版信息

Br J Pharmacol. 1981 Jan;72(1):13-5. doi: 10.1111/j.1476-5381.1981.tb09098.x.

DOI:10.1111/j.1476-5381.1981.tb09098.x
PMID:6261863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2071548/
Abstract

The benzomorphans, ethylketazocine, bremazocine and MR 2034 are pure agonists in the guinea-pig ileum and mouse vas deferens but are competitive antagonists without agonist activity in the rat vas deferens.

摘要

苯并吗啡烷类、乙基酮佐辛、布马佐辛和MR 2034在豚鼠回肠和小鼠输精管中是纯激动剂，但在大鼠输精管中是没有激动剂活性的竞争性拮抗剂。

相似文献

1
Unexpected antagonism in the rat vas deferens by benzomorphans which are agonists in other pharmacological tests.在其他药理学试验中为激动剂的苯并吗啡烷类药物在大鼠输精管中出现意外的拮抗作用。
Br J Pharmacol. 1981 Jan;72(1):13-5. doi: 10.1111/j.1476-5381.1981.tb09098.x.
2
Assessment in the guinea-pig ileum and mouse vas deferens of benzomorphans which have strong antinociceptive activity but do not substitute for morphine in the dependent monkey.对具有强抗伤害感受活性但在依赖的猴子中不能替代吗啡的苯并吗啡烷类药物在豚鼠回肠和小鼠输精管中的评估。
Br J Pharmacol. 1975 Dec;55(4):541-6. doi: 10.1111/j.1476-5381.1975.tb07430.x.
3
Agonist and antagonist actions of buprenorphine on three types of opioid receptor in isolated preparations.丁丙诺啡对离体标本中三种阿片受体的激动和拮抗作用。
Jpn J Pharmacol. 1986 Jan;40(1):95-101. doi: 10.1254/jjp.40.95.
4
In vitro study of the interaction of salmon calcitonin with mu, delta and kappa opioid agonists.鲑鱼降钙素与μ、δ和κ阿片样激动剂相互作用的体外研究。
Naunyn Schmiedebergs Arch Pharmacol. 1993 Mar;347(3):324-8. doi: 10.1007/BF00167452.
5
Bremazocine: a potent, long-acting opiate kappa-agonist.布瑞马佐辛：一种强效、长效的阿片κ受体激动剂。
Life Sci. 1980 Sep 15;27(11):971-8. doi: 10.1016/0024-3205(80)90107-1.
6
Diprenorphine has agonist activity at opioid kappa-receptors in the myenteric plexus of the guinea-pig ileum.二丙诺啡对豚鼠回肠肌间神经丛中的阿片κ受体具有激动活性。
Eur J Pharmacol. 1987 May 7;137(1):85-9. doi: 10.1016/0014-2999(87)90185-3.
7
Assessment of the kappa-opioid activity of a series of 6,7-benzomorphans in the rabbit vas deferens.一系列6,7-苯并吗啡烷在兔输精管中的κ-阿片样活性评估。
Eur J Pharmacol. 1988 Aug 9;153(1):83-7. doi: 10.1016/0014-2999(88)90590-0.
8
Comparison of the opioid activity of CAM and kappa agonists.CAM与κ阿片受体激动剂的阿片样物质活性比较。
NIDA Res Monogr. 1986;75:224-7.
9
Agonist and antagonist opioid activity of axial and equatorial conformations of S-methyl- and S-allyl-morphinans.S-甲基和S-烯丙基吗啡喃的轴向和赤道构象的阿片类激动剂和拮抗剂活性
Eur J Pharmacol. 1994 Jun 2;258(1-2):111-8. doi: 10.1016/0014-2999(94)90063-9.
10
The effects of the selective kappa-opioid agonist MR 2034 on the guinea-pig ileum.选择性κ-阿片受体激动剂MR 2034对豚鼠回肠的作用。
J Pharm Pharmacol. 1988 May;40(5):378-80. doi: 10.1111/j.2042-7158.1988.tb05274.x.

引用本文的文献

1
-Acetyl β-Endorphin Is an Endogenous Ligand of σ1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for σ2Rs in σ1R Oligomers.乙酰-β-内啡肽是 σ1Rs 的内源性配体，通过在 σ1R 寡聚体中交换 G 蛋白为 σ2Rs，调节 μ 阿片受体信号。
Int J Mol Sci. 2022 Dec 29;24(1):582. doi: 10.3390/ijms24010582.
2
Bremazocine: a kappa-opioid agonist with potent analgesic and other pharmacologic properties.布瑞马佐辛：一种具有强效镇痛及其他药理特性的κ阿片受体激动剂。
CNS Drug Rev. 2005 Summer;11(2):195-212. doi: 10.1111/j.1527-3458.2005.tb00270.x.
3
The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties.具有不同激动剂和拮抗剂特性的麻醉性镇痛药的结合光谱。
Naunyn Schmiedebergs Arch Pharmacol. 1982 Jun;319(3):197-205. doi: 10.1007/BF00495865.
4
Opioid effects in developing rat vas deferens.阿片类药物对发育中的大鼠输精管的作用。
Cell Mol Neurobiol. 1981 Dec;1(4):335-42. doi: 10.1007/BF00716268.
5
Postjunctional inhibition of contractor responses in the mouse vas deferens by rat and human calcitonin gene-related peptides (CGRP).大鼠和人降钙素基因相关肽（CGRP）对小鼠输精管收缩反应的接头后抑制作用
Br J Pharmacol. 1986 May;88(1):173-80. doi: 10.1111/j.1476-5381.1986.tb09484.x.
6
Bremazocine differentially antagonizes responses to selective mu and delta opioid receptor agonists in rat hippocampus.布瑞马佐辛对大鼠海马体中选择性μ和δ阿片受体激动剂的反应具有差异性拮抗作用。
Br J Pharmacol. 1987 Jul;91(3):523-30. doi: 10.1111/j.1476-5381.1987.tb11245.x.
7
Effects of cations on binding, in membrane suspensions, of various opioids at mu-sites of rabbit cerebellum and kappa-sites of guinea-pig cerebellum.阳离子对兔小脑μ位点和豚鼠小脑κ位点上各种阿片类药物在膜悬浮液中结合的影响。
Br J Pharmacol. 1987 Jun;91(2):431-7. doi: 10.1111/j.1476-5381.1987.tb10298.x.
8
Bremazocine is an agonist at kappa-opioid receptors and an antagonist at mu-opioid receptors in the guinea-pig myenteric plexus.布雷马佐辛是豚鼠肠肌丛中κ-阿片受体的激动剂和μ-阿片受体的拮抗剂。
Br J Pharmacol. 1986 Sep;89(1):245-9. doi: 10.1111/j.1476-5381.1986.tb11141.x.
9
Pre-incubation of guinea-pig myenteric plexus with beta-funaltrexamine: discrepancy between binding assays and bioassays.用β-芬太尼环已胺对豚鼠肠肌丛进行预孵育：结合试验与生物测定之间的差异。
Br J Pharmacol. 1985 Jul;85(3):665-73. doi: 10.1111/j.1476-5381.1985.tb10562.x.
10
Aversive properties of naloxone in non-dependent (naive) rats may involve blockade of central beta-endorphin.纳洛酮在非依赖性（未接触过药物的）大鼠中的厌恶特性可能涉及对中枢β-内啡肽的阻断。
Psychopharmacology (Berl). 1985;86(3):281-5. doi: 10.1007/BF00432214.

本文引用的文献

1
Some quantitative uses of drug antagonists.药物拮抗剂的一些定量应用。
Br J Pharmacol Chemother. 1959 Mar;14(1):48-58. doi: 10.1111/j.1476-5381.1959.tb00928.x.
2
Characterization of opioid receptors in nervous tissue.神经组织中阿片受体的特性研究。
Proc R Soc Lond B Biol Sci. 1980 Oct 29;210(1178):113-22. doi: 10.1098/rspb.1980.0122.
3
The effects of morphine and nalorphine-like drugs in the nondependent, morphine-dependent and cyclazocine-dependent chronic spinal dog.吗啡及纳洛芬样药物对未成瘾、吗啡成瘾及环唑辛成瘾的慢性脊髓犬的作用。
J Pharmacol Exp Ther. 1976 Jul;198(1):66-82.
4
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.吗啡样和烯丙吗啡样药物在非依赖性和吗啡依赖性慢性脊髓犬中的作用
J Pharmacol Exp Ther. 1976 Jun;197(3):517-32.
5
Rat vas deferens: a specific bioassay for endogenous opioid peptides.大鼠输精管：一种用于内源性阿片肽的特异性生物测定法。
Br J Pharmacol. 1978 Nov;64(3):327-9. doi: 10.1111/j.1476-5381.1978.tb08653.x.
6
Selective receptors for beta-endorphin on the rat vas deferens.大鼠输精管上β-内啡肽的选择性受体。
Life Sci. 1979 Feb 26;24(9):843-9. doi: 10.1016/0024-3205(79)90368-0.
7
Assessment in the guinea-pig ileum and mouse vas deferens of benzomorphans which have strong antinociceptive activity but do not substitute for morphine in the dependent monkey.对具有强抗伤害感受活性但在依赖的猴子中不能替代吗啡的苯并吗啡烷类药物在豚鼠回肠和小鼠输精管中的评估。
Br J Pharmacol. 1975 Dec;55(4):541-6. doi: 10.1111/j.1476-5381.1975.tb07430.x.