McCarty K S, Grant J W, Georgiade N, Wilkinson W, Graham R, Ferguson B J, Deubner D, McCarty K S, Seigler H F
Cancer. 1981 Jul 1;48(1):69-75. doi: 10.1002/1097-0142(19810701)48:1<69::aid-cncr2820480115>3.0.co;2-m.
Using direct imunofluorescence, lesions from 266 human breast specimens were studied for the presence of IgA, IgM, or IgG localization. The lesions included benign elements from 66 subcutaneous mastectomy specimens in which the absence of simultaneous breast malignancy was documented, primary breast carcinomas from 153 mastectomy specimens, and 47 biopsies containing metastatic breast cancer. A statistically significant association of IgA and IgM with benign lesions was contrasted to the association of IgG with malignant lesions. In both primary and metastatic lesions, IgG localization was associated with estrogen-receptor-poor primary cancers as compared with estrogen-receptor-rich primary cancers. Among primary breast cancer patients, IgG localization in the tumor correlated with relative lymphopenia. A shorter disease-free interval was noted in association with IgG localization among the metastatic breast lesions. No statistically significant association between stage of disease and immunoglobulin presence was demonstrable. Moderate-to-severe intraductal epithelial hyperplasias were more often associated with immunoglobulin G localization that were other benign lesions.
利用直接免疫荧光法，对266例人类乳腺标本的病变进行了研究，以检测IgA、IgM或IgG的定位情况。这些病变包括66例皮下乳房切除术标本中的良性成分（已记录无同时存在的乳腺恶性肿瘤）、153例乳房切除术标本中的原发性乳腺癌以及47例含有转移性乳腺癌的活检标本。将IgA和IgM与良性病变的统计学显著关联与IgG与恶性病变的关联进行了对比。在原发性和转移性病变中，与富含雌激素受体的原发性癌症相比，IgG定位与雌激素受体缺乏的原发性癌症相关。在原发性乳腺癌患者中，肿瘤中的IgG定位与相对淋巴细胞减少相关。在转移性乳腺病变中，IgG定位与无病生存期较短有关。未发现疾病分期与免疫球蛋白存在之间有统计学显著关联。中重度导管内上皮增生比其他良性病变更常与免疫球蛋白G定位相关。
