Aiyoshi Y, Yamashita K, Fujimoto Y
Endocrinol Jpn. 1980 Oct;27(5):625-30. doi: 10.1507/endocrj1954.27.625.
The effect of TSH (100mU/ml) and norepinephrine (100 muM) on the cyclic AMP levels was studied in 10 human normal tissues, 10 thyroid adenomas and 4 thyroid carcinomas (3 papillary and 1 follicular). Normal tissues responded to TSH with a marked elevation of the cyclic AMP level. Response patterns of 10 thyroid adenomas to TSH were variable; the patterns of 6 cases resembled those of normal tissues, 3 responded mildly, and one had no response to TSH. Thyroid carcinomas had a higher basal level of cyclic AMP than those of normal tissues, although they responded only slightly to TSH. Two among 4 thyroid carcinomas had no response to TSH. Norepinephrine stimulated the accumulation of cyclic AMP in 4 thyroid adenomas and 3 thyroid carcinomas, while it had little effect on normal tissues. Responses to norepinephrine was observed only in thyroid tumors, although they had low response to TSH. It is suggested from these results that tumor cells originating from thyroid follicular cells have a modified response to hormones due to neoplastic alterations.
研究了促甲状腺激素（100mU/ml）和去甲肾上腺素（100μM）对10例正常人体组织、10例甲状腺腺瘤和4例甲状腺癌（3例乳头状癌和1例滤泡状癌）中环磷酸腺苷水平的影响。正常组织对促甲状腺激素反应为环磷酸腺苷水平显著升高。10例甲状腺腺瘤对促甲状腺激素的反应模式各不相同；6例的模式类似于正常组织，3例反应轻微，1例对促甲状腺激素无反应。甲状腺癌的环磷酸腺苷基础水平高于正常组织，尽管它们对促甲状腺激素的反应仅轻微。4例甲状腺癌中有2例对促甲状腺激素无反应。去甲肾上腺素刺激了4例甲状腺腺瘤和3例甲状腺癌中环磷酸腺苷的积累，而对正常组织几乎没有影响。仅在甲状腺肿瘤中观察到对去甲肾上腺素的反应，尽管它们对促甲状腺激素反应较低。从这些结果表明，起源于甲状腺滤泡细胞的肿瘤细胞由于肿瘤性改变而对激素有改变的反应。
