Hughes J H, Hamparian V V
J Clin Microbiol. 1981 May;13(5):824-7. doi: 10.1128/jcm.13.5.824-827.1981.
The incorporation of hyperimmune serum into cell culture medium to control endogenous viral infections of primary cells can have a significant effect on the replication of other viruses. When commercial simian virus 5 or simian virus 40 antiserum was used with primary monkey kidney cell cultures, we found a significant inhibition (greater than 90%) of the replication of parainfluenza virus types 2 and 3 and reovirus type 1. In the viral diagnostic laboratory, the use of hyperimmune serum with primary monkey kidney cells may result in failure to isolate certain viruses if these cells are not first washed free of hyperimmune serum.
将超免疫血清加入细胞培养基以控制原代细胞的内源性病毒感染，可能会对其他病毒的复制产生显著影响。当将商业性猿猴病毒5或猿猴病毒40抗血清与原代猴肾细胞培养物一起使用时，我们发现副流感病毒2型和3型以及呼肠孤病毒1型的复制受到显著抑制（超过90%）。在病毒诊断实验室中，如果不先将原代猴肾细胞中的超免疫血清洗去，使用超免疫血清可能会导致无法分离出某些病毒。
