1型单纯疱疹病毒诱导的蛋白激酶的分离
Isolation of a protein kinase induced by herpes simplex virus type 1.
作者信息
Blue W T, Stobbs D G
出版信息
J Virol. 1981 Apr;38(1):383-8. doi: 10.1128/JVI.38.1.383-388.1981.
Abstract
We have isolated a new cyclic AMP-independent protein kinase activity induced in HeLa cells by infection with herpes simplex virus type 1. Induction of the enzyme does not occur in cells treated with cycloheximide at the time of infection, or in cells infected with UV-inactivated herpes simplex virus type 1. The amount of enzyme induced in infected cells is dependent upon the multiplicity of infection. An enzyme with identical properties to the appearing in infected HeLa cells is also induced by herpes simplex virus type 1 in BHK cells.
摘要
我们已经分离出一种新的不依赖环磷酸腺苷的蛋白激酶活性，它是由1型单纯疱疹病毒感染HeLa细胞诱导产生的。在用环己酰亚胺处理的感染时的细胞中，或者在用紫外线灭活的1型单纯疱疹病毒感染的细胞中，该酶不会被诱导产生。感染细胞中诱导产生的酶量取决于感染复数。1型单纯疱疹病毒在BHK细胞中也能诱导出一种与感染的HeLa细胞中出现的具有相同性质的酶。
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