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1型单纯疱疹病毒诱导的蛋白激酶的分离

Isolation of a protein kinase induced by herpes simplex virus type 1.

作者信息

Blue W T, Stobbs D G

出版信息

J Virol. 1981 Apr;38(1):383-8. doi: 10.1128/JVI.38.1.383-388.1981.

DOI:10.1128/JVI.38.1.383-388.1981
PMID:6264111
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171163/
Abstract

We have isolated a new cyclic AMP-independent protein kinase activity induced in HeLa cells by infection with herpes simplex virus type 1. Induction of the enzyme does not occur in cells treated with cycloheximide at the time of infection, or in cells infected with UV-inactivated herpes simplex virus type 1. The amount of enzyme induced in infected cells is dependent upon the multiplicity of infection. An enzyme with identical properties to the appearing in infected HeLa cells is also induced by herpes simplex virus type 1 in BHK cells.

摘要

我们已经分离出一种新的不依赖环磷酸腺苷的蛋白激酶活性，它是由1型单纯疱疹病毒感染HeLa细胞诱导产生的。在用环己酰亚胺处理的感染时的细胞中，或者在用紫外线灭活的1型单纯疱疹病毒感染的细胞中，该酶不会被诱导产生。感染细胞中诱导产生的酶量取决于感染复数。1型单纯疱疹病毒在BHK细胞中也能诱导出一种与感染的HeLa细胞中出现的具有相同性质的酶。

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本文引用的文献

1
Herpes simplex virus phosphoproteins. II. Characterization of the virion protein kinase and of the polypeptides phosphorylated in the virion.单纯疱疹病毒磷蛋白。II. 病毒体蛋白激酶及病毒体中磷酸化多肽的特性
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Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA.单纯疱疹病毒磷蛋白。I. 磷酸基团在一些病毒多肽上循环进出，并且能够改变它们对DNA的亲和力。
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Temperature-sensitive kinase activity associated with various mutants of avian sarcoma viruses which are temperature sensitive for transformation.与对转化温度敏感的禽肉瘤病毒各种突变体相关的温度敏感性激酶活性。
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Protein kinase and specific phosphate acceptor proteins associated with vaccinia virus cores.与痘苗病毒核心相关的蛋白激酶和特定磷酸受体蛋白。
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Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins.疱疹病毒大分子合成的调控。I. 三组病毒蛋白合成的级联调控。
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Virion-bound protein kinase in Semliki forest and Sindbis viruses.辛德毕斯病毒和塞姆利基森林病毒中的病毒体结合蛋白激酶。
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Virology. 1972 Feb;47(2):536-8. doi: 10.1016/0042-6822(72)90297-8.
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Protein kinase and phosphate acceptor proteins in Rauscher murine leukaemia virus.劳氏鼠白血病病毒中的蛋白激酶和磷酸受体蛋白
Nat New Biol. 1971 Sep 29;233(39):137-40. doi: 10.1038/newbio233137a0.