Kodama M, Saito T, Ogawa T, Tokuda G, Sasahara J, Kumagai T
Natl Inst Anim Health Q (Tokyo). 1980 Winter;20(4):123-30.
An infection experiment was carried out on pigs with swine vesicular disease virus isolated from healthy pigs (SVDV-H). Inoculation was done by two routes, intradermal in the coronary band of the foot and oral. Observation was made on the formation of vesicles and their spread, the virus contents of serum, swab of the oral cavity, and feces, the vicissitude of neutralizing antibody titers, and the distribution of virus in the body. From its results the pathogenicity of virus was judged. In the pigs inoculated intradermally there was a difference in the extension of the area involved in vesicular formation between any two strains of virus. That is, vesicular formation was restricted to the site of inoculation, involved the site of inoculation and the sole of the hoof, or spread over the oral and nasal regions. In every pig, however, vesicles developed only for 2 approximately 5 days after inoculation. After that, repair progressed rapidly. Some strains caused viremia, which was mild. The virus was detected from the site of vesicular formation, but not from any organ. Neutralizing antibody began to be detected 3 days after inoculation. Its titer reached a plateau about 10 days later. In the pigs inoculated perorally, no vesicles were formed. The virus was only detected from the tonsils and the intestinal contents. These findings made it clear that SVDV-H was less pathogenic than swine vesicular disease virus isolated from diseased pigs.
用从健康猪分离出的猪水疱病病毒（SVDV - H）对猪进行感染实验。接种通过两种途径进行，即皮内接种于足部冠状带和口服。观察水疱的形成及其扩散情况、血清、口腔拭子和粪便中的病毒含量、中和抗体效价的变化以及病毒在体内的分布。根据实验结果判断病毒的致病性。在皮内接种的猪中，任何两株病毒在水疱形成所涉及区域的扩展方面存在差异。也就是说，水疱形成局限于接种部位、涉及接种部位和蹄底，或者扩散到口鼻区域。然而，每头猪在接种后水疱仅出现约2至5天。之后，修复迅速进行。一些毒株引起轻度病毒血症。在水疱形成部位检测到病毒，但在任何器官中均未检测到。接种后3天开始检测到中和抗体。其效价约10天后达到稳定水平。在口服接种的猪中，未形成水疱。仅在扁桃体和肠道内容物中检测到病毒。这些结果表明，SVDV - H的致病性低于从患病猪分离出的猪水疱病病毒。
