Smith K O, Kennell W
Infect Immun. 1981 Aug;33(2):491-7. doi: 10.1128/iai.33.2.491-497.1981.
Many individuals who are seronegative for one member of the human Herpesviridae family are strongly seropositive for other members. Using sera from such individuals, the radioimmunoassay technique demonstrated absence of antigen-antibody cross-reactions between varicella-zoster virus (VZV) and herpes simplex virus (HSV) at levels of less than one part in 1,000. Sera containing antibody to both HSV and VZV were absorbed with antigens of one agent without significantly altering the amount of remaining antibody to the other antigen. This further suggests that HSV and VZV do not share a common antigen. The same radioimmunoassay technique and serum absorption method that revealed no serological cross-reactions between HSV and VZV revealed the expected cross-reaction between HSV type 1 (HSV-1) and HSV-2. Reciprocally absorbed anti-HSV-1 and anti-HSV 2 sera were able to differentiate the two HSV types reliably. No cross-reactions were seen between cytomegalovirus, VZV, and HSV or between Epstein-Barr virus, VZV, and HSV. We postulate that heterotypic antibody responses sometimes observed for VZV after primary infections by HSV may not be due to shared antigens, but to activation of latent VZV infections, release of new VZV antigens, and consequent stimulation of new antibody production to VZV.
许多人对人类疱疹病毒科的一个成员血清学呈阴性，但对其他成员血清学呈强阳性。利用这些人的血清，放射免疫测定技术表明，水痘带状疱疹病毒（VZV）和单纯疱疹病毒（HSV）之间在低于千分之一的水平上不存在抗原抗体交叉反应。含有HSV和VZV抗体的血清用一种病毒的抗原进行吸收，而不会显著改变对另一种抗原的剩余抗体量。这进一步表明HSV和VZV不共享共同抗原。揭示HSV和VZV之间无血清学交叉反应的相同放射免疫测定技术和血清吸收方法，揭示了1型单纯疱疹病毒（HSV-1）和2型单纯疱疹病毒（HSV-2）之间预期的交叉反应。相互吸收的抗HSV-1和抗HSV-2血清能够可靠地区分这两种HSV类型。在巨细胞病毒、VZV和HSV之间或在爱泼斯坦-巴尔病毒、VZV和HSV之间未观察到交叉反应。我们推测，HSV初次感染后VZV有时观察到的异型抗体反应可能不是由于共享抗原，而是由于潜伏性VZV感染的激活、新VZV抗原的释放以及随后对VZV新抗体产生的刺激。
