Carp R I
Intervirology. 1981;15(1):49-56. doi: 10.1159/000149214.
Exposure of several spontaneously transformed human lymphoid cell lines to attenuated and virulent types 1 and 2 poliovirus strains led to an initial sharp increase in virus titer followed by a persistent infection. Virus was present as late as 80 passages after infection. The morphology, cell count and viability of virus- and mock-infected cells were similar. Approximately 1% of the cells scored as infectious centers, and the cultures could be cured by specific antiserum. Virus produced during persistent infections initiated with a virus that readily forms plaques at 40 degrees, Mahoney virus, showed an increase in temperature sensitivity and a decrease in plaque size.
几种自发转化的人类淋巴细胞系暴露于减毒和强毒的1型及2型脊髓灰质炎病毒株后，病毒滴度最初急剧上升，随后出现持续感染。感染后80代仍可检测到病毒。病毒感染组和模拟感染组细胞的形态、细胞计数和活力相似。约1%的细胞被计为感染中心，且培养物可用特异性抗血清治愈。由在40℃易形成蚀斑的病毒（马奥尼病毒）引发的持续感染过程中产生的病毒，其温度敏感性增加，蚀斑大小减小。
