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B组柯萨奇病毒很容易在人类淋巴细胞系中建立持续性感染。

Group B coxsackieviruses readily establish persistent infections in human lymphoid cell lines.

作者信息

Matteucci D, Paglianti M, Giangregorio A M, Capobianchi M R, Dianzani F, Bendinelli M

出版信息

J Virol. 1985 Nov;56(2):651-4. doi: 10.1128/JVI.56.2.651-654.1985.

Abstract

Exposing human lymphoid cell lines to uncloned or recently cloned group B coxsackieviruses results in the frequent establishment of chronically infected cultures. Persistence is maintained by a carrier culture mechanism involving virus spread through the medium and replication among a minority of cells at any given time. These studies provide a model for persistence by highly cytocidal viruses.

摘要

将人类淋巴细胞系暴露于未克隆或最近克隆的B组柯萨奇病毒中,常常会导致建立起慢性感染培养物。持续性感染通过一种载体培养机制得以维持,该机制涉及病毒在培养基中的传播以及在任何给定时间少数细胞间的复制。这些研究为高细胞毒性病毒的持续性感染提供了一个模型。

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