Badrinas F, Buendia E, Mestre M, Sisó C, Barberá G, Garrigosa R
Med Clin (Barc). 1981 Jul 15;77(3):108-14.
Between April 1976 and February 1980, serum levels of angiotensin-converting enzyme were determined in 61 cases of sarcoidosis at different stages of evolution. Cases were divided in three groups on the basis of social determinations done every 3-6 months. In the group with 46 active cases the increase in mean value of the enzyme is statistically significant compared to the control group; 30 of these (65.2%) had values higher than + 2DS. In the second group with 24 cases of non-progressive or inactive sarcoidosis the mean value was slightly higher than the normal mean value, without being statistically significant; 21 patients (87.5%) showed normal values: in the third group with 19 patients who had been treated with corticosteroids, mean value was equal to normal values; after 12 months treatment values were normal in 17 cases (89.5%). In the control group of 80 patients with a variety of pulmonary diseases other than sarcoidosis (pulmonary tuberculosis, pneumonia, pulmonary thromboembolism and primary lung cancer) only 9 cases presented values higher than the normal + 2SD (11.2% false positive). Serial determination of angiotensin-converting enzyme is a useful diagnostic parameter in sarcoidosis; especially in evaluating progression of the disease as well as the efficacy of corticosteroid treatment.
1976年4月至1980年2月期间，对61例处于不同演变阶段的结节病患者测定了血清血管紧张素转换酶水平。根据每3 - 6个月进行的病情判定，将病例分为三组。在46例活动期病例组中，与对照组相比，该酶平均值的升高具有统计学意义；其中30例（65.2%）的值高于+2DS。在第二组24例非进行性或非活动期结节病患者中，平均值略高于正常平均值，但无统计学意义；21例患者（87.5%）显示值正常：在第三组19例接受皮质类固醇治疗的患者中，平均值等于正常值；治疗12个月后，17例患者（89.5%）的值正常。在80例患有除结节病之外的各种肺部疾病（肺结核、肺炎、肺血栓栓塞症和原发性肺癌）的对照组中，只有9例的值高于正常+2SD（假阳性率为11.2%）。连续测定血管紧张素转换酶是结节病中一个有用的诊断参数；尤其在评估疾病进展以及皮质类固醇治疗效果方面。
