Silverstein E, Friedland J, Kitt M, Lyons H A
Isr J Med Sci. 1977 Oct;13(10):995-1000.
The activity of serum angiotensin converting enzyme (ACE), assayed fluorometrically with the substrate hippuryl-L-histidyl-L-leucine was significantly higher in 116 patients with sarcoidosis than in 415 patients with other diseases--pulmonary and nonpulmonary--and in 58 normal subjects. Serum ACE was elevated in 59% of 46 recently diagnosed, untreated patients with sarcoidosis and was significantly reduced following steroid therapy in three patients with sarcoidosis, but in only one of four patients treated with placebos. The results suggest that elevated serum ACE activity is a valuable, although not absolutely specific, diagnostic indicator of sarcoidosis. It should be stressed that a normal value does not rule out the disease, and that steroid therapy tends to reduce the serum ACE activity.
用马尿酰-L-组氨酰-L-亮氨酸作为底物，采用荧光法测定血清血管紧张素转换酶（ACE）活性，结果显示，116例结节病患者的血清ACE活性显著高于415例患有其他疾病（包括肺部疾病和非肺部疾病）的患者以及58例正常受试者。46例近期诊断且未接受治疗的结节病患者中，59%的患者血清ACE升高；3例接受类固醇治疗的结节病患者血清ACE显著降低，而4例接受安慰剂治疗的患者中只有1例血清ACE降低。结果表明，血清ACE活性升高是结节病的一个有价值的诊断指标，尽管并非绝对特异。需要强调的是，正常数值并不能排除该病，而且类固醇治疗往往会降低血清ACE活性。
