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AKR白血病胸腺中缺乏AKR嗜亲性前病毒扩增。

Lack of AKR ecotropic provirus amplification in AKR leukemic thymuses.

作者信息

Yoshimura F K, Breda M

出版信息

J Virol. 1981 Sep;39(3):808-15. doi: 10.1128/JVI.39.3.808-815.1981.

DOI:10.1128/JVI.39.3.808-815.1981
PMID:6270352
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC171313/
Abstract

A DNA fragment from the 3' region of a molecularly cloned AKR ecotropic provirus was identified to be specific for the AKR ecotropic murine leukemia virus (MuLV). This selected DNA fragment was used to analyze the integrated MuLV proviruses in normal and leukemic tissue DNAs of AKR mice. In comparison with a DNA fragment from the 5' region of the cloned AKR genome or one representing the entire genome, this selected probe hybridized to only a few MuLV proviruses. By comparing transformed and nontransformed tissue DNAs, it appeared that no amplification of proviral sequences related to the AKR ecotropic MuLV had occurred in thymomas of AKR mice during the development of leukemia in these animals. Analysis of the AKR ecotropic MuLV proviruses revealed a significant degree of polymorphism for these sequences among individuals in the AKR/J strain of mouse.

摘要

从分子克隆的AKR嗜亲性前病毒3'区域获得的一个DNA片段被鉴定为对AKR嗜亲性鼠白血病病毒（MuLV）具有特异性。这个挑选出的DNA片段用于分析AKR小鼠正常组织和白血病组织DNA中整合的MuLV前病毒。与克隆的AKR基因组5'区域的一个DNA片段或代表整个基因组的片段相比，这个挑选出的探针仅与少数MuLV前病毒杂交。通过比较转化组织和未转化组织的DNA，发现在这些动物白血病发生过程中，AKR小鼠胸腺瘤中与AKR嗜亲性MuLV相关的前病毒序列没有扩增。对AKR嗜亲性MuLV前病毒的分析显示，在AKR/J品系小鼠个体之间，这些序列存在显著程度的多态性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51b/171313/a45819b7c5cf/jvirol00009-0159-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51b/171313/e88219486095/jvirol00009-0156-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51b/171313/1109a639c210/jvirol00009-0156-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51b/171313/f392fb095fdf/jvirol00009-0157-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51b/171313/fc74535179b9/jvirol00009-0158-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51b/171313/a45819b7c5cf/jvirol00009-0159-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51b/171313/e88219486095/jvirol00009-0156-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51b/171313/1109a639c210/jvirol00009-0156-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51b/171313/f392fb095fdf/jvirol00009-0157-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51b/171313/fc74535179b9/jvirol00009-0158-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51b/171313/a45819b7c5cf/jvirol00009-0159-a.jpg

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本文引用的文献

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Proc Natl Acad Sci U S A. 1980 Oct;77(10):5774-8. doi: 10.1073/pnas.77.10.5774.
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Germ-line reinsertions of AKR murine leukemia virus genomes in Akv-1 congenic mice.Akv-1同源小鼠中AKR鼠白血病病毒基因组的种系重新插入。
Proc Natl Acad Sci U S A. 1980 Aug;77(8):4871-4. doi: 10.1073/pnas.77.8.4871.
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Evidence for the Asiatic origin of endogenous AKR-type murine leukemia proviruses.内源性AKR型鼠白血病前病毒亚洲起源的证据。
对分子克隆且具有生物活性的莫洛尼貂细胞病灶形成前病毒DNA的env基因进行分析。
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Linkage of the Fv-2 gene to a newly reinserted ecotropic retrovirus in Fv-2 congenic mice.Fv-2基因与Fv-2同源基因小鼠中新插入的亲嗜性逆转录病毒的连锁关系。
J Virol. 1983 Sep;47(3):471-7. doi: 10.1128/JVI.47.3.471-477.1983.
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Strong selection for cells containing new ecotropic recombinant murine leukemia virus provirus after propagation of C57BL/6 radiation-induced thymoma cells in vitro or in vivo.在体外或体内培养C57BL/6辐射诱导的胸腺瘤细胞后，对含有新的嗜亲性重组鼠白血病病毒前病毒的细胞进行强烈选择。
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