Motomura R, Mori H, Teramoto C, Nishimura Y, Souda Y, Yamabe T
Jpn J Antibiot. 1981 Apr;34(4):521-31.
Fundamental and clinical studies were made on cefotaxime (CTX), a new cephalosporin antibiotic. The following results were obtained: 1. Antibacterial activity: At a concentration of 3.13 mcg/ml, CTX inhibited the growth of 90.2% of 92 strains of Gram-negative rods and 80.0% of 15 strains of Gram-positive cocci. 2. Concentrations of CTX in body fluids and genital organs after 2 g i.v.: (1) CTX level in pus reached the peak (5.6mcg/ml) at 2 hours after administration. (2) Mean CTX levels in the pelvic space exudate reached the peak (28.0 mcg/ml) at 2 hours after administration. (3) CTX levels in the uterine appendages and uterus reached the peak (8.9 and 4.5 mcg/g, respectively) at 100 to 280 minutes after administration. 3.
CTX was excellent in 7 of 13 cases and good in the remaining 6 cases. The response rate to CTX was 100%. 4. The bacteriological effect: The bacteriological effect of CTX was also 100%. Bacteria were eradicated in 7 of the 10 cases where organisms were demonstrated before CTX treatment. Partial reduction bacteria was observed in the remaining 3 cases. 5. No side effect attributable to CTX was observed.
对新型头孢菌素抗生素头孢噻肟（CTX）进行了基础和临床研究。获得了以下结果：1.抗菌活性：在浓度为3.13微克/毫升时，CTX抑制了92株革兰氏阴性杆菌中90.2%的生长以及15株革兰氏阳性球菌中80.0%的生长。2.静脉注射2克后CTX在体液和生殖器官中的浓度：（1）给药后2小时脓液中CTX水平达到峰值（5.6微克/毫升）。（2）盆腔渗出液中CTX平均水平在给药后2小时达到峰值（28.0微克/毫升）。（3）给药后100至280分钟子宫附件和子宫中的CTX水平达到峰值（分别为8.9和4.5微克/克）。3.临床结果：13例中有7例CTX效果极佳，其余6例效果良好。CTX的有效率为100%。4.细菌学效果：CTX的细菌学效果也为100%。在CTX治疗前有微生物检测结果的10例病例中，7例细菌被根除。其余3例观察到细菌部分减少。5.未观察到归因于CTX的副作用。
