Hayasaki M, Iwasa S, Noda K, Itoh K
Jpn J Antibiot. 1981 Apr;34(4):489-94.
Ten cases of gynecological infection were treated successfully by a new cephalosporin derivative, cefotaxime (HR 756, CTX), which proved excellent in 4 cases and good in 6 cases. No adverse reaction was found to be induced by administration of this drug. Post-administration results were all normal for both renal and hepatic function tests. It is extremely difficult to accurately assess bacteriological efficacy of a drug in treatment of female genital infections. Nevertheless, we determined its MICs for a few number of strains we could isolate from clinical cases. Its MIC against 4 strains of B. fragilis inoculated at 10(8) cells/ml was 25 approximately 50 mcg/ml and was 1.56 approximately 3.13 mcg/ml at 10(6) cells/ml inoculation. Its MIC against 2 strains of Ps. cepacia was 12.5 mcg/ml at 10(8) cells/ml inoculation and 6.25 mcg/ml at 10(6) cells/ml inoculation. These MICs suggest that this drug is a very promising antimicrobial agent for treatment of gynecological infections, as been already indicated by clinical results of this drug.
10例妇科感染患者采用新型头孢菌素衍生物头孢噻肟（HR 756，CTX）治疗成功，其中4例效果极佳，6例效果良好。未发现使用该药物引起不良反应。用药后肾功能和肝功能检查结果均正常。准确评估药物治疗女性生殖器感染的细菌学疗效极为困难。尽管如此，我们还是测定了从临床病例中分离出的少数菌株的最低抑菌浓度（MIC）。其对以10⁸个细胞/毫升接种的4株脆弱拟杆菌的MIC约为25至50微克/毫升，以10⁶个细胞/毫升接种时为1.56至3.13微克/毫升。其对2株洋葱伯克霍尔德菌以10⁸个细胞/毫升接种时的MIC为12.5微克/毫升，以10⁶个细胞/毫升接种时为6.25微克/毫升。这些MIC表明，该药物是一种极有前景的治疗妇科感染的抗菌剂，该药物的临床结果已表明了这一点。
