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Differential affinities of 5-(2-halogenovinyl)-2'-deoxyuridines for deoxythymidine kinases of various origins.

作者信息

Cheng Y C, Dutschman G, De Clercq E, Jones A S, Rahim S G, Verhelst G, Walker R T

出版信息

Mol Pharmacol. 1981 Jul;20(1):230-3.

PMID:6270535
Abstract
摘要

相似文献

1
Differential affinities of 5-(2-halogenovinyl)-2'-deoxyuridines for deoxythymidine kinases of various origins.5-（2-卤代乙烯基）-2'-脱氧尿苷对不同来源的脱氧胸苷激酶的差异亲和力。
Mol Pharmacol. 1981 Jul;20(1):230-3.
2
Selective antiherpetic activity of carbocyclic analogues of (E)-5-(2-halogenovinyl)-2'-deoxyuridines: dependence on specific phosphorylation by viral thymidine kinase.（E）-5-（2-卤代乙烯基）-2'-脱氧尿苷碳环类似物的选择性抗疱疹活性：依赖于病毒胸苷激酶的特异性磷酸化作用。
Biochem Biophys Res Commun. 1985 Jan 16;126(1):397-403. doi: 10.1016/0006-291x(85)90619-9.
3
Differential inhibition of herpes simplex viruses, type 1 (HSV-1) an type 2 (HSV-2), by (E)-5-(2-X-vinyl)-2'-deoxyuridines.（E）-5-（2-X-乙烯基）-2'-脱氧尿苷对1型单纯疱疹病毒（HSV-1）和2型单纯疱疹病毒（HSV-2）的差异抑制作用
Acta Microbiol Acad Sci Hung. 1981;28(3):307-12.
4
Differential binding affinities of sugar-modified derivatives of (E)-5-(2-bromovinyl)-2'-deoxyuridine for herpes simplex virus-induced and human cellular deoxythymidine kinases.
Biochem Pharmacol. 1984 Jun 1;33(11):1797-800. doi: 10.1016/0006-2952(84)90352-6.
5
Differential phosphorylation of (E)-5-(2-bromovinyl)-2'-deoxyuridine monophosphate by thymidylate kinases from herpes simplex viruses types 1 and 2 and varicella zoster virus.单纯疱疹病毒1型和2型以及水痘带状疱疹病毒的胸苷酸激酶对（E）-5-（2-溴乙烯基）-2'-脱氧尿苷单磷酸的差异磷酸化作用
Mol Pharmacol. 1982 Mar;21(2):432-7.
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5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells.阿拉伯糖胞苷和2'-脱氧尿苷的5-炔基类似物：对单纯疱疹病毒和水痘-带状疱疹胸苷激酶基因转染细胞的细胞生长抑制活性
J Med Chem. 2007 Jun 14;50(12):2851-7. doi: 10.1021/jm0701472. Epub 2007 May 23.
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Antiviral activities and phosphorylation of 5-halo-2'-deoxyuridines and N-methanocarbathymidine in cells infected with vaccinia virus.牛痘病毒感染细胞中5-卤代-2'-脱氧尿苷和N-甲氧基碳胸腺嘧啶的抗病毒活性及磷酸化作用
Antivir Chem Chemother. 2008;19(1):15-24. doi: 10.1177/095632020801900103.
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5-Bromovinyl 2'-deoxyuridine phosphorylation by mitochondrial and cytosolic thymidine kinase (TK2 and TK1) and its use in selective measurement of TK2 activity in crude extracts.线粒体和胞质胸苷激酶（TK2和TK1）对5-溴乙烯基2'-脱氧尿苷的磷酸化作用及其在粗提物中TK2活性选择性测定中的应用。
Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):858-62. doi: 10.1080/15257770802146510.
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Virus-induced thymidine kinases as markers for typing herpes simplex viruses and for drug sensitivity assays.病毒诱导的胸苷激酶作为单纯疱疹病毒分型及药敏试验的标志物。
J Virol Methods. 1982 Nov;5(3-4):209-17. doi: 10.1016/0166-0934(82)90011-8.
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Interactions between virus and antiviral compounds in the host cell.病毒与宿主细胞中抗病毒化合物之间的相互作用。
Med Biol. 1984;62(6):299-303.

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Analysis of antiviral drug properties of thymidine kinase of herpes B virus using recombinant herpes simplex virus 1.利用重组单纯疱疹病毒 1 分析疱疹 B 病毒胸苷激酶的抗病毒药物特性。
Microbiol Spectr. 2024 Jan 11;12(1):e0309123. doi: 10.1128/spectrum.03091-23. Epub 2023 Dec 14.
2
Chapter 3 Antiviral drugs: general considerations.第3章 抗病毒药物：一般考虑因素。
Perspect Med Virol. 1985;1:93-126. doi: 10.1016/S0168-7069(08)70011-9. Epub 2008 May 29.
3
Distribution and effects of amino acid changes in drug-resistant α and β herpesviruses DNA polymerase.
耐药性α和β疱疹病毒DNA聚合酶中氨基酸变化的分布及影响
Nucleic Acids Res. 2016 Nov 16;44(20):9530-9554. doi: 10.1093/nar/gkw875. Epub 2016 Sep 29.
4
Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine.水痘带状疱疹病毒胸苷酸合成酶的结构与人类酶建立了功能和结构上的相似性，并使其自身成为布立伏定的作用靶点。
PLoS One. 2015 Dec 2;10(12):e0143947. doi: 10.1371/journal.pone.0143947. eCollection 2015.
5
Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.猴B病毒（猕猴疱疹病毒1型）对抗病毒药物的敏感性：胸苷激酶在底物类似物和无环核苷抗病毒活性中的作用
Antimicrob Agents Chemother. 2007 Jun;51(6):2028-34. doi: 10.1128/AAC.01284-06. Epub 2007 Apr 16.
6
Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2.用于线粒体胸苷激酶-2的强效和选择性抑制剂的新型呋喃核糖核苷先导化合物。
Biochem J. 2000 Oct 1;351(Pt 1):167-71. doi: 10.1042/0264-6021:3510167.
7
Treatment of experimental herpes simplex virus encephalitis with (E)-5-(2-bromovinyl)-2'-deoxyuridine in mice.用（E）-5-（2-溴乙烯基）-2'-脱氧尿苷治疗小鼠实验性单纯疱疹病毒性脑炎。
Antimicrob Agents Chemother. 1982 Sep;22(3):421-5. doi: 10.1128/AAC.22.3.421.
8
Modified polynucleotides. VI. Properties of a synthetic DNA containing the anti-herpes agent (E)-5-(2-bromovinyl)-2'-deoxyuridine.修饰多核苷酸。VI. 一种含有抗疱疹剂（E）-5-（2-溴乙烯基）-2'-脱氧尿苷的合成DNA的性质
Nucleic Acids Res. 1982 Oct 11;10(19):6051-66. doi: 10.1093/nar/10.19.6051.
9
Regeneration of the antiviral drug (E)-5-(2-bromovinyl)-2'-deoxyuridine in vivo.抗病毒药物（E）-5-（2-溴乙烯基）-2'-脱氧尿苷的体内再生。
Nucleic Acids Res. 1984 Feb 24;12(4):2081-90. doi: 10.1093/nar/12.4.2081.
10
Effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on proliferation of human fibroblasts, peripheral blood mononuclear cells, and granulocyte-monocyte progenitor cells in vitro.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷对人成纤维细胞、外周血单个核细胞和粒细胞-单核细胞祖细胞体外增殖的影响。
Antimicrob Agents Chemother. 1983 Nov;24(5):803-6. doi: 10.1128/AAC.24.5.803.