Koivunen E, Grönhagen-Riska C, Klockars M, Selroos O
Acta Med Scand. 1981;210(1-2):107-10. doi: 10.1111/j.0954-6820.1981.tb09784.x.
Serum lysozyme (LZM) concentrations were correlated to the number of neutrophils and monocytes in patients with sarcoidosis and nongranulomatous diseases. In sarcoidosis patients with an increased activity of serum angiotensin converting enzyme (ACE), a positive correlation was noted between LZM and blood monocytes. In sarcoidosis patients with normal ACE activity, as well as in patients with non-granulomatous diseases, a correlation was found between blood neutrophils and LZM, but not between blood monocytes and LZM. LZM was found in bone marrow plasma and in serum in a ratio of 1.5 to 1. Sarcoidosis patients had 30% higher LZM levels than healthy controls. The concentration of LZM in bone marrow plasma did not correlate to detectable granulomas in bone marrow specimens. The positive correlation between blood monocytes and LZM in patients with clinically active sarcoidosis is possibly due to recruitment of bone marrow monocytes for the granuloma formation.
血清溶菌酶（LZM）浓度与结节病和非肉芽肿性疾病患者的中性粒细胞及单核细胞数量相关。在血清血管紧张素转换酶（ACE）活性升高的结节病患者中，LZM与血液单核细胞之间存在正相关。在ACE活性正常的结节病患者以及非肉芽肿性疾病患者中，发现血液中性粒细胞与LZM之间存在相关性，但血液单核细胞与LZM之间无相关性。骨髓血浆和血清中LZM的比例为1.5比1。结节病患者的LZM水平比健康对照者高30%。骨髓血浆中LZM的浓度与骨髓标本中可检测到的肉芽肿无相关性。临床活动期结节病患者血液单核细胞与LZM之间的正相关可能是由于骨髓单核细胞被募集用于肉芽肿形成。
