Selroos O, Grönhagen-Riska C
Scand J Respir Dis. 1979 Dec;60(6):328-36.
The activity of serum angiotensin converting enzyme (ACE) was repeatedly measured together with serum lysozyme (LZM) in patients with untreated sarcoidosis. Changes in the clinical picture were registered using chest X-ray, forced vital capacity (FVC), diffusing capacity for carbon monoxide (DLCO) and appearance of extrapulmonary lesions. During a clinically unchanged period the highest ACE activity and the corresponding LZM value (not the highest value) were used for the calculation. A statistically significant change in ACE was noted when a normal chest X-ray changed to a stage II lesion or vice versa, and when a signficant change in FVC occurred. All other changes were insignificant. On the other hand, statistically significant changes in ACE were found during stable periods according to chest X-ray, FVC or DLCO. ACE is frequently elevated in serum of patients with active sarcoidosis. The fluctuations in activity mostly parallel the clinical course of the disease. The behaviour and metabolism of the enzyme need further investigation. An increased concentration of serum LZM is frequent in patients with active sarcoidosis. The highest LZM values are not always seen simultaneously with the highest ACE values, indicating that they probably express different dimensions of the disturbances in the sarcoid granuloma.
对未经治疗的结节病患者反复测量血清血管紧张素转换酶（ACE）活性，并同时检测血清溶菌酶（LZM）。使用胸部X线、用力肺活量（FVC）、一氧化碳弥散量（DLCO）以及肺外病变的出现情况来记录临床表现的变化。在临床症状无变化的时期，采用最高的ACE活性及相应的LZM值（而非最高值）进行计算。当正常胸部X线转变为II期病变或反之，以及FVC出现显著变化时，ACE出现具有统计学意义的改变。所有其他变化均无统计学意义。另一方面，根据胸部X线、FVC或DLCO处于稳定期时，ACE也出现了具有统计学意义的变化。活动性结节病患者血清中的ACE常常升高。其活性波动大多与疾病的临床进程平行。该酶的行为和代谢需要进一步研究。活动性结节病患者血清LZM浓度常常升高。最高的LZM值并不总是与最高的ACE值同时出现，这表明它们可能反映了结节病肉芽肿病变的不同方面。
