Chu C C
J Biomed Mater Res. 1981 Nov;15(6):795-804. doi: 10.1002/jbm.820150604.
Tensile strength of poly(glycolic acid) suture (PGA) of size 2-0 was examined as a function of three pH levels, 5.25, 7.44, and 10.09 of the buffer. Cord and yarn grip was used to eliminate grip-induced failure of breaking strength tests. It was found that Dexon sutures degraded significantly faster in pH = 10.09 buffer than the other two lower pH buffers. There was no significant difference in degradation rate at pH = 5.25 and 7.44. At 7 days, PGA sutures lost almost half of its original tensile strength at pH = 10.09, while the same sutures still remained more than 95% of their original breaking strength at buffers of pH = 5.25 and 7.44. After 21 days, no trace of sutures could be detected in the buffer of pH = 10.09 while about 20% strength still remained in the buffers of pH = 7.44 and 5.25. Cage effect in the crystalline phase and pH dependent hydrogen bonding were introduced to explain the difference in degradation phenomenon of PGA at buffers of various pH.
研究了2-0规格的聚乙醇酸缝线（PGA）的拉伸强度与三种pH值（5.25、7.44和10.09）缓冲液的关系。使用绳索和纱线夹具以消除夹具引起的断裂强度测试失败。结果发现，Dexon缝线在pH = 10.09的缓冲液中降解速度明显快于其他两种较低pH值的缓冲液。在pH = 5.25和7.44时，降解速率没有显著差异。在7天时，PGA缝线在pH = 10.09时失去了几乎一半的原始拉伸强度，而在pH = 5.25和7.44的缓冲液中，相同的缝线仍保留其原始断裂强度的95%以上。21天后，在pH = 10.09的缓冲液中未检测到缝线痕迹，而在pH = 7.44和5.25的缓冲液中仍保留约20%的强度。引入晶相中的笼效应和pH依赖性氢键来解释PGA在不同pH缓冲液中降解现象的差异。
