Chu C C
J Biomed Mater Res. 1982 Mar;16(2):117-24. doi: 10.1002/jbm.820160204.
The pH effect on the hydrolytic degradation of Polyglactin 910 copolymer was studied in terms of the tensile properties of the suture specimens. The use of a cord/yarn grip, newly designed specifically for fibrous materials, eliminated the grip-induced failure. Different degrees of hydrolytic degradation of this copolymer at 3 different pH levels were observed. The suture specimens exhibited the best retentions of breaking strength at the physiological pH of 7.44, while the specimens at pH = 10.09 showed the fastest loss of breaking strength. Thus, a maximum retention of tensile properties occurred around the pH level of 7.0, whereas smaller percentages of retention of tensile properties were observed at both acidic and strong alkaline solutions. This synthetic absorbable suture material exhibits the basic characteristic of hydrolysis which is catalyzed by both acid and base.
根据缝合线样本的拉伸性能，研究了pH值对聚乙交酯丙交酯910共聚物水解降解的影响。专门为纤维材料新设计的绳/纱夹具的使用消除了夹具引起的失效。观察到该共聚物在3种不同pH水平下有不同程度的水解降解。缝合线样本在生理pH值7.44时表现出最佳的断裂强度保留率，而pH = 10.09时的样本断裂强度损失最快。因此，在pH值7.0左右出现了拉伸性能的最大保留率，而在酸性和强碱性溶液中观察到的拉伸性能保留率百分比则较小。这种合成可吸收缝合线材料表现出由酸和碱催化的水解基本特征。
